GPC5 Gene - Glypican 5
A heparan sulfate proteoglycan involved in cell growth, differentiation, and cancer susceptibility
Gene Information Card
| Symbol | GPC5 |
|---|---|
| Full Name | Glypican 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q31.3 |
| NCBI Gene ID | 2262 ncbi.nlm.nih.gov/gene/2262 |
| Ensembl ID | ENSG00000179399 |
| UniProt ID | P78333 |
| OMIM ID | 600352 |
| HGNC ID | 4454 |
| Aliases | GPC-5, glypican-5 |
Description
GPC5 (glypican 5) is a member of the glypican family of heparan sulfate proteoglycans, which are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans play roles in cell growth, differentiation, and migration by modulating signaling pathways such as Wnt, Hedgehog, and fibroblast growth factors. GPC5 is implicated in several cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered GPC5 expression may influence Wnt signaling and tumor progression | PMID: 25691885 (NCBI) |
| Lung cancer | GPC5 polymorphisms associated with susceptibility; overexpression in non-small cell lung cancer | PMID: 20676098 (NCBI) |
| Ovarian cancer | GPC5 copy number gains and overexpression linked to poor prognosis | PMID: 23593055 (NCBI) |
| Simpson-Golabi-Behmel syndrome (SGBS) | GPC5 mutations may contribute to the phenotype, though GPC3 is primary | OMIM 600352 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Lung | 6.1 | Low |
| Breast | 4.2 | Low |
| Ovary | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 5.0 | Moderate expression |
| A549 (lung cancer) | 7.2 | Elevated expression |
| HEK293 (embryonic kidney) | 4.5 | Low expression |
| SKOV3 (ovarian cancer) | 6.8 | Elevated expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation of protein |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function; premature stop |
| c.890A>G (p.Asn297Ser) | Missense | 0.2% | Unknown effect; rare variant |
| c.1456C>T (p.Arg486Cys) | Missense | 0.1% | Unknown effect; rare variant |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (p.Arg412*, p.Trp189*) lead to truncated, non-functional protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (Reactome: R-HSA-195721)
• Hedgehog signaling pathway (Reactome: R-HSA-5358351)
• Glypican pathway (Reactome: R-HSA-1650814)
Protein Summary
Glypican-5 (UniProt P78333) is a 572-amino acid heparan sulfate proteoglycan anchored to the plasma membrane via GPI. It carries heparan sulfate chains that interact with growth factors, morphogens, and extracellular matrix components. GPC5 modulates signaling pathways critical for development and is dysregulated in various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPC5 Knockout HEK293 Cell Line | EDJ-KQ4590 | Human | 2262 | Details Get a Quote |
| GPC5 Knockout HeLa Cell Line | EDJ-KQ27252 | Human | 2262 | Details Get a Quote |
| GPC5 Knockout A-549 Cell Line | EDJ-KQ61711 | Human | 2262 | Details Get a Quote |
| GPC5 Knockout HCT 116 Cell Line | EDJ-KQ70196 | Human | 2262 | Details Get a Quote |
