GP2 (Glycoprotein 2)
Zymogen Granule Membrane Glycoprotein and Autoantigen in Crohn's Disease
Gene Information Card
| Symbol | GP2 |
|---|---|
| Full Name | Glycoprotein 2 (zymogen granule membrane) |
| Gene Type | protein-coding |
| Chromosomal Location | 16p12.3 |
| NCBI Gene ID | 2813 ncbi.nlm.nih.gov/gene/2813 |
| Ensembl ID | ENSG00000169302 |
| UniProt ID | P55259 |
| OMIM ID | 600753 |
| HGNC ID | 4435 |
| Aliases | MUC13, PZP |
Description
GP2 encodes glycoprotein 2, a heavily glycosylated protein anchored to the zymogen granule membrane in pancreatic acinar cells. It is released into pancreatic juice and serves as a major autoantigen in Crohn's disease, particularly recognized by anti-glycoprotein 2 antibodies (anti-GP2). GP2 also functions in bacterial binding and immune modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Crohn's disease | Autoantibodies against GP2 target pancreatic zymogen granule membrane, contributing to intestinal inflammation | ClinVar, OMIM |
| Pancreatitis | GP2 autoantibodies detected in autoimmune pancreatitis; potential diagnostic marker | NCBI Gene, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 112.3 | High |
| Salivary gland | 12.1 | Medium |
| Stomach | 8.5 | Medium |
| Small intestine | 5.2 | Low |
| Colon | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 45.6 | Pancreatic cancer cell line |
| Capan-2 | 38.2 | Pancreatic adenocarcinoma |
| BxPC-3 | 29.8 | Pancreatic adenocarcinoma |
| HPAF-II | 33.1 | Pancreatic adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.01% | p.Pro412Ser; uncertain significance |
| c.567G>A | missense | <0.01% | p.Arg189Gln; uncertain significance |
| c.890_891insA | frameshift | <0.01% | p.Thr297fs; loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.890_891insA) predicted to truncate protein, reducing membrane anchoring and secretion.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • extracellular region |
| • membrane | • zymogen granule |
| • immune response |
Pathways
• Pancreatic secretion
• Autoimmune response to self-antigens
Protein Summary
Glycoprotein 2 (GP2) is a 522-amino-acid type I membrane protein with a large extracellular domain rich in O-glycosylation sites. It is expressed on zymogen granule membranes in pancreatic acinar cells and is secreted into pancreatic juice. GP2 binds bacteria via fimbrial adhesins and is a target of autoantibodies in Crohn's disease, where it may drive intestinal inflammation through cross-reactivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GP2 Knockout HEK293 Cell Line | EDJ-KQ4744 | Human | 2813 | Details Get a Quote |
| GP2 Knockout HeLa Cell Line | EDJ-KQ53378 | Human | 2813 | Details Get a Quote |
| GP2 Knockout A-549 Cell Line | EDJ-KQ61854 | Human | 2813 | Details Get a Quote |
| GP2 Knockout HCT 116 Cell Line | EDJ-KQ70339 | Human | 2813 | Details Get a Quote |
| GP2a Overexpression MARC-145 Stable Cell Line | EDC90690 | Green monkey | / | Details Get a Quote |
