GORASP2
Golgi Reassembly Stacking Protein 2
Gene Information Card
| Symbol | GORASP2 |
|---|---|
| Full Name | Golgi Reassembly Stacking Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 26003 ncbi.nlm.nih.gov/gene/26003 |
| Ensembl ID | ENSG00000115947 |
| UniProt ID | Q9H8Y8 |
| OMIM ID | 606867 |
| HGNC ID | 24981 |
| Aliases | GRASP55, GOLPH5, p65 |
Description
GORASP2 (Golgi Reassembly Stacking Protein 2) encodes a protein that plays a critical role in the stacking of Golgi cisternae and the reassembly of the Golgi apparatus after mitosis. It functions as a membrane tethering factor and is involved in protein transport and secretion. The protein localizes to the Golgi apparatus and interacts with other Golgi matrix proteins.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered GORASP2 expression may affect Golgi structure and secretory pathways, contributing to tumor progression. | COSMIC; PubMed studies |
| Neurodegenerative disorders | Dysregulation of Golgi reassembly and protein trafficking linked to neuronal dysfunction. | PubMed; limited evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Pancreas | 10.2 | Medium |
| Liver | 8.9 | Medium |
| Kidney | 7.6 | Low |
| Brain | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | High expression |
| HEK293 | 12.8 | High expression |
| A549 | 10.1 | Medium expression |
| MCF7 | 8.4 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in GORASP2.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • Golgi organization | • Golgi vesicle transport |
| • protein homooligomerization | • Golgi membrane |
| • protein binding |
Pathways
• Golgi reassembly
• ER to Golgi transport
• Vesicle-mediated transport
Protein Summary
GORASP2 encodes GRASP55, a 55 kDa Golgi reassembly stacking protein that localizes to the Golgi apparatus. It is essential for maintaining Golgi structure and function, particularly during mitotic reassembly. The protein contains a GRASP domain and interacts with other Golgi matrix components to tether Golgi membranes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GORASP2 Knockout HEK293 Cell Line | EDJ-KQ224 | Human | 26003 | Details Get a Quote |
| GORASP2 Knockout HCT 116 Cell Line | EDJ-KQ33031 | Human | 26003 | Details Get a Quote |
| GORASP2 Knockout A-549 Cell Line | EDJ-KQ34367 | Human | 26003 | Details Get a Quote |
| GORASP2 Knockout HeLa Cell Line | EDJ-KQ34369 | Human | 26003 | Details Get a Quote |
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