GOLM1 Gene: Function, Expression, and Role in Cancer | NCBI, UniProt

GOLM1 (Golgi Membrane Protein 1), also known as GP73, is a protein-coding gene located on chromosome 9q21.33. It encodes a type II Golgi transmembrane protein that localizes to the cis-Golgi cisternae. GOLM1 is involved in protein trafficking, Golgi structure maintenance, and secretory pathway regulation. It is highly expressed in epithelial cells and is a well-established serum biomarker for hepatocellular carcinoma (HCC). Overexpression of GOLM1 promotes cancer cell proliferation, migration, and invasion through multiple signaling pathways, including EGFR/AKT and Wnt/β-catenin.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• EGFR signaling pathway

• Wnt/β-catenin signaling pathway

• PI3K/AKT signaling pathway

• Epithelial-to-mesenchymal transition

GOLM1 is a 73 kDa type II Golgi transmembrane protein encoded by the GOLM1 gene. It is primarily localized to the cis-Golgi and plays a role in maintaining Golgi structure and facilitating protein trafficking. The protein is cleaved and secreted into serum, where it serves as a biomarker for hepatocellular carcinoma. GOLM1 interacts with EGFR to sustain AKT signaling and promotes cancer cell proliferation and metastasis. Its expression is upregulated in various cancers and correlates with poor prognosis.