GNG8
G Protein Subunit Gamma 8
Gene Information Card
| Symbol | GNG8 |
|---|---|
| Full Name | G Protein Subunit Gamma 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 94235 ncbi.nlm.nih.gov/gene/94235 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q9UK08 |
| OMIM ID | 608981 |
| HGNC ID | 4402 |
| Aliases | GNG8, G protein gamma 8, GNGT8 |
Description
GNG8 encodes a member of the G protein gamma subunit family. This protein is a component of heterotrimeric G protein complexes, which couple seven-transmembrane domain receptors to intracellular signaling pathways. GNG8 is involved in signal transduction, particularly in sensory and neuronal tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Testis | 3.8 | Low |
| Retina | 2.1 | Not detected |
| Heart | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| SH-SY5Y | 1.2 | Low expression |
| K562 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • signal transduction |
| • heterotrimeric G-protein complex | • GTPase activity |
Pathways
• GPCR downstream signaling
• cAMP signaling pathway
Protein Summary
GNG8 is a 71-amino acid gamma subunit of heterotrimeric G proteins. It forms a complex with G beta and G alpha subunits to modulate intracellular signaling cascades. Expression is enriched in brain and testis, suggesting roles in neuronal and reproductive signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GNG8 Knockout HEK293 Cell Line | EDJ-KQ802 | Human | 94235 | Details Get a Quote |
| GNG8 Knockout HeLa Cell Line | EDJ-KQ57887 | Human | 94235 | Details Get a Quote |
| GNG8 Knockout A-549 Cell Line | EDJ-KQ66383 | Human | 94235 | Details Get a Quote |
| GNG8 Knockout HCT 116 Cell Line | EDJ-KQ74807 | Human | 94235 | Details Get a Quote |
