GNG5B Gene: Function, Location, and Clinical Significance | Biomedical Database

GNG5B is a gene located on chromosome 5q35.3 that encodes a putative G protein subunit gamma 5-like protein. It is derived from a retrocopy of the GNG5 gene and is considered a processed pseudogene, though it retains an open reading frame and shows evidence of transcription. Its biological function is not fully characterized, but it may play a role in modulating G protein signaling pathways. Expression data suggest low to moderate activity in certain tissues, but no disease associations have been established.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• G protein signaling (inferred from sequence similarity to GNG5)

The GNG5B protein is a small, putative gamma subunit of heterotrimeric G proteins. It shares sequence similarity with GNG5, but its functional significance is unclear. It may interact with G protein beta subunits to form functional dimers, but experimental validation is lacking. The protein is predicted to be membrane-associated via prenylation at its C-terminus, a common feature of G protein gamma subunits.