GNG10 Gene - G Protein Subunit Gamma 10
A key component of heterotrimeric G-protein complexes involved in signal transduction.
Gene Information Card
| Symbol | GNG10 |
|---|---|
| Full Name | G Protein Subunit Gamma 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q31.3 |
| NCBI Gene ID | 2790 ncbi.nlm.nih.gov/gene/2790 |
| Ensembl ID | ENSG00000106991 |
| UniProt ID | P50151 |
| OMIM ID | 604389 |
| HGNC ID | 4407 |
| Aliases | GNG10, G gamma-10 |
Description
GNG10 encodes the gamma 10 subunit of heterotrimeric G proteins. This subunit is part of the G protein complex that couples seven-transmembrane domain receptors to intracellular signaling pathways. The gamma subunit is essential for proper receptor-G protein interaction and signal transduction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Brain cortex | 8.3 | Low |
| Heart muscle | 6.1 | Low |
| Liver | 4.2 | Low |
| Lung | 9.7 | Low |
| Skeletal muscle | 3.8 | Low |
| Spleen | 7.4 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical carcinoma cells |
| K562 | 6.5 | Leukemia cells |
| MCF7 | 5.9 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | No functional data available |
| c.100C>T | synonymous | <0.01% | No functional data available |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway (GO:0007186) | • heterotrimeric G-protein complex (GO:0005834) |
| • signal transducer activity (GO:0004871) | • GTPase activity (GO:0003924) |
Pathways
• GPCR downstream signaling (Reactome R-HSA-388396)
• G alpha (i) signaling events (Reactome R-HSA-418594)
• G alpha (s) signaling events (Reactome R-HSA-418555)
Protein Summary
The gamma 10 subunit is a small protein (approximately 7 kDa) that forms a stable dimer with the beta subunit. This beta-gamma complex is essential for modulating G protein-coupled receptor (GPCR) signaling. GNG10 is widely expressed but shows highest levels in testis and adipose tissue. No disease-causing mutations have been firmly established.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GNG10 Knockout HEK293 Cell Line | EDJ-KQ1215 | Human | 2790 | Details Get a Quote |
| GNG10 Knockout A-549 Cell Line | EDJ-KQ20537 | Human | 2790 | Details Get a Quote |
| GNG10 Knockout HCT 116 Cell Line | EDJ-KQ20538 | Human | 2790 | Details Get a Quote |
| GNG10 Knockout HeLa Cell Line | EDJ-KQ20539 | Human | 2790 | Details Get a Quote |
| DNAJC25-GNG10 Knockout HEK293 Cell Line | EDJ-KQ52368 | Human | 552891 | Details Get a Quote |
| DNAJC25-GNG10 Knockout HeLa Cell Line | EDJ-KQ60503 | Human | 552891 | Details Get a Quote |
| DNAJC25-GNG10 Knockout A-549 Cell Line | EDJ-KQ68973 | Human | 552891 | Details Get a Quote |
| DNAJC25-GNG10 Knockout HCT 116 Cell Line | EDJ-KQ77331 | Human | 552891 | Details Get a Quote |
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