GMFG (Glia Maturation Factor Gamma)
Actin-binding protein involved in cytoskeletal dynamics and immune cell function
Gene Information Card
| Symbol | GMFG |
|---|---|
| Full Name | Glia Maturation Factor Gamma |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 9535 ncbi.nlm.nih.gov/gene/9535 |
| Ensembl ID | ENSG00000130558 |
| UniProt ID | O60234 |
| OMIM ID | 601893 |
| HGNC ID | 4384 |
| Aliases | GMF, GMF-gamma |
Description
GMFG (Glia Maturation Factor Gamma) is a protein-coding gene that encodes a member of the glia maturation factor family. The protein is an actin-binding protein that regulates actin filament dynamics, particularly in immune cells such as neutrophils and macrophages. It plays a role in cell migration, phagocytosis, and cytoskeletal reorganization. GMFG is predominantly expressed in hematopoietic tissues and is involved in inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory disorders | GMFG regulates neutrophil chemotaxis and actin polymerization; dysregulation may contribute to excessive inflammation. | NCBI Gene, UniProt |
| Cancer (potential) | Altered GMFG expression may affect tumor cell migration and invasion via cytoskeletal remodeling. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | High |
| Spleen | 10.8 | High |
| Lymph node | 9.2 | Medium |
| Blood | 8.5 | Medium |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (leukemia) | 15.3 | High expression |
| K-562 (leukemia) | 12.1 | High expression |
| HeLa (cervical) | 2.5 | Low expression |
| A549 (lung) | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.214A>G (p.Thr72Ala) | Missense | <0.1% | Unknown functional effect |
| c.367C>T (p.Arg123Trp) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding (GO:0003779) | • actin filament organization (GO:0007015) |
| • actin cytoskeleton organization (GO:0030036) | • actin filament bundle assembly (GO:0051017) |
| • plasma membrane (GO:0005886) |
Pathways
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• Fc gamma R-mediated phagocytosis (KEGG: hsa04666)
• Chemokine signaling pathway (KEGG: hsa04062)
Protein Summary
The GMFG protein (UniProt O60234) is a 142-amino acid actin-binding protein that belongs to the ADF/cofilin family. It promotes actin filament severing and depolymerization, regulating cytoskeletal dynamics essential for cell motility and immune function. The protein is highly expressed in hematopoietic cells and localizes to the cytoplasm and plasma membrane.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GMFG Knockout HEK293 Cell Line | EDJ-KQ6626 | Human | 9535 | Details Get a Quote |
| GMFG Knockout HeLa Cell Line | EDJ-KQ29528 | Human | 9535 | Details Get a Quote |
| GMFG Knockout A-549 Cell Line | EDJ-KQ63671 | Human | 9535 | Details Get a Quote |
| GMFG Knockout HCT 116 Cell Line | EDJ-KQ72133 | Human | 9535 | Details Get a Quote |
