GLYATL2 Gene - Glycine-N-Acyltransferase Like 2
Comprehensive genomic and functional annotation of GLYATL2
Gene Information Card
| Symbol | GLYATL2 |
|---|---|
| Full Name | Glycine-N-Acyltransferase Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 340267 ncbi.nlm.nih.gov/gene/340267 |
| Ensembl ID | ENSG00000187608 |
| UniProt ID | Q8WU03 |
| OMIM ID | 614279 |
| HGNC ID | 26887 |
| Aliases | ACGNAT, GLYATL, GLYATL1 |
Description
GLYATL2 (Glycine-N-Acyltransferase Like 2) is a protein-coding gene that encodes an acyltransferase enzyme involved in the conjugation of glycine with various acyl-CoA substrates. This gene is part of the glycine N-acyltransferase family and is primarily expressed in liver and kidney tissues, where it plays a role in detoxification and metabolism of endogenous and exogenous carboxylic acids.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated in OMIM or ClinVar | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small Intestine | 4.1 | Low |
| Colon | 3.2 | Low |
| Adrenal Gland | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| HEK293 | 6.5 | Embryonic kidney cell line |
| Caco-2 | 3.8 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations documented in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Glycine conjugation of benzoyl-CoA (Reactome: R-HSA-156588)
• Phase II conjugation of carboxylic acids (Reactome: R-HSA-156587)
Protein Summary
The GLYATL2 protein (UniProt Q8WU03) is a 296-amino acid acyltransferase localized to the cytoplasm. It catalyzes the transfer of an acyl group from acyl-CoA to glycine, producing N-acylglycine and CoA. This enzyme is important for the detoxification of xenobiotics and the metabolism of endogenous acyl-CoA esters. The protein contains a conserved N-acyltransferase domain and is expressed predominantly in liver and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GLYATL2 Knockout HEK293 Cell Line | EDJ-KQ7775 | Human | 219970 | Details Get a Quote |
| GLYATL2 Knockout HeLa Cell Line | EDJ-KQ59121 | Human | 219970 | Details Get a Quote |
| GLYATL2 Knockout A-549 Cell Line | EDJ-KQ67595 | Human | 219970 | Details Get a Quote |
| GLYATL2 Knockout HCT 116 Cell Line | EDJ-KQ75986 | Human | 219970 | Details Get a Quote |
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