GLYATL1 Gene
Glycine-N-Acyltransferase Like 1
Gene Information Card
| Symbol | GLYATL1 |
|---|---|
| Full Name | Glycine-N-Acyltransferase Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 92292 ncbi.nlm.nih.gov/gene/92292 |
| Ensembl ID | ENSG00000149196 |
| UniProt ID | Q969I3 |
| OMIM ID | 614774 |
| HGNC ID | 24867 |
| Aliases | ACGNAT, GLYATL, GLYATL1A |
Description
GLYATL1 (Glycine-N-Acyltransferase Like 1) is a protein-coding gene that encodes an acyltransferase enzyme involved in the conjugation of glycine with various acyl-CoA substrates. This gene is part of the glycine N-acyltransferase family and is primarily expressed in liver and kidney, playing a role in detoxification and metabolism of endogenous and exogenous carboxylic acids.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated in ClinVar or OMIM for GLYATL1 | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small intestine | 4.1 | Low |
| Colon | 2.7 | Low |
| Adipose tissue | 1.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Liver cancer cell line |
| HEK293 | 3.5 | Embryonic kidney |
| Caco-2 | 2.1 | Colorectal adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar for GLYATL1 | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations documented in ClinVar or COSMIC for GLYATL1.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • acyltransferase activity (GO:0016746) | • C-acyltransferase activity (GO:0016408) |
| • transferase activity (GO:0016747) | • cytoplasm (GO:0005737) |
Pathways
• Glycine conjugation of benzoic acid (Reactome: R-HSA-177128)
• Phase II conjugation of xenobiotics (Reactome: R-HSA-156588)
Protein Summary
The GLYATL1 protein (UniProt Q969I3) is a 296-amino acid acyltransferase localized in the cytoplasm. It catalyzes the transfer of an acyl group from acyl-CoA to glycine, producing N-acylglycine and CoA. This reaction is important for the detoxification of xenobiotics and the metabolism of endogenous acyl-CoA esters. The enzyme shows highest expression in liver and kidney, consistent with its role in metabolic clearance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GLYATL1 Knockout HEK293 Cell Line | EDJ-KQ10864 | Human | 92292 | Details Get a Quote |
| GLYATL1B Knockout HEK293 Cell Line | EDJ-KQ13612 | Human | 100287520 | Details Get a Quote |
| GLYATL1 Knockout HeLa Cell Line | EDJ-KQ57834 | Human | 92292 | Details Get a Quote |
| GLYATL1 Knockout A-549 Cell Line | EDJ-KQ66332 | Human | 92292 | Details Get a Quote |
| GLYATL1 Knockout HCT 116 Cell Line | EDJ-KQ74757 | Human | 92292 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
