GLP2R (Glucagon Like Peptide 2 Receptor)
A G protein-coupled receptor for glucagon-like peptide-2, involved in intestinal growth and function.
Gene Information Card
| Symbol | GLP2R |
|---|---|
| Full Name | Glucagon Like Peptide 2 Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 9340 ncbi.nlm.nih.gov/gene/9340 |
| Ensembl ID | ENSG00000165392 |
| UniProt ID | O95838 |
| OMIM ID | 603659 |
| HGNC ID | 4271 |
| Aliases | GLP-2R, GLP2R_HUMAN |
Description
GLP2R encodes the glucagon-like peptide 2 receptor (GLP-2R), a G protein-coupled receptor (GPCR) that binds glucagon-like peptide-2 (GLP-2). GLP-2R is primarily expressed in the gastrointestinal tract and plays a critical role in promoting intestinal epithelial cell proliferation, nutrient absorption, and mucosal integrity. Activation of GLP-2R stimulates cAMP production and downstream signaling pathways that regulate intestinal growth and function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Short bowel syndrome | GLP-2R activation by exogenous GLP-2 (teduglutide) enhances intestinal adaptation and absorption | Clinical trials and FDA approval |
| Crohn disease | GLP-2R signaling may reduce inflammation and promote mucosal healing | Observational studies and clinical trials |
| Intestinal failure | GLP-2R agonists improve nutrient absorption and reduce parenteral nutrition dependence | Clinical evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small intestine | 12.5 | High |
| Colon | 8.3 | Medium |
| Stomach | 5.1 | Medium |
| Pancreas | 2.0 | Low |
| Lung | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 15.2 | Colorectal adenocarcinoma cell line |
| HT-29 | 10.1 | Colorectal adenocarcinoma cell line |
| HCT 116 | 7.8 | Colorectal carcinoma cell line |
| HEK 293 | 0.5 | Embryonic kidney cell line (low expression) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of function; start codon loss |
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Unknown functional effect |
| c.200C>T (p.Pro67Leu) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Mutations that disrupt receptor expression or GLP-2 binding, such as start codon loss, are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been reported in GLP2R.
Dominant Negative (DN)
No dominant-negative mutations have been described for GLP2R.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • glucagon-like peptide 2 receptor activity |
| • cAMP-mediated signaling | • positive regulation of cell population proliferation |
| • intestinal epithelial cell proliferation |
Pathways
• GLP-2 receptor signaling pathway
• GPCR downstream signaling
• cAMP signaling pathway
Protein Summary
The GLP-2 receptor is a 553-amino acid protein with seven transmembrane domains characteristic of class B GPCRs. It is activated by GLP-2, leading to Gs protein coupling and increased intracellular cAMP. The receptor is essential for mediating the intestinotrophic effects of GLP-2, including stimulation of crypt cell proliferation, inhibition of apoptosis, and enhancement of nutrient transport.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GLP2R Knockout HEK293 Cell Line | EDJ-KQ2577 | Human | 9340 | Details Get a Quote |
| GLP2R Knockout HeLa Cell Line | EDJ-KQ21893 | Human | 9340 | Details Get a Quote |
| GLP2R Knockout A-549 Cell Line | EDJ-KQ23261 | Human | 9340 | Details Get a Quote |
| GLP2R Knockout HCT 116 Cell Line | EDJ-KQ72076 | Human | 9340 | Details Get a Quote |
