GLIPR1L1 Gene: GLI Pathogenesis Related 1 Like 1
Comprehensive genomic and functional overview of GLIPR1L1
Gene Information Card
| Symbol | GLIPR1L1 |
|---|---|
| Full Name | GLI pathogenesis related 1 like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q21.2 |
| NCBI Gene ID | 340392 ncbi.nlm.nih.gov/gene/340392 |
| Ensembl ID | ENSG00000185499 |
| UniProt ID | Q6ZMU5 |
| OMIM ID | 617787 |
| HGNC ID | 26897 |
| Aliases | GLIPR1L, GLIPR1-like 1 |
Description
GLIPR1L1 (GLI Pathogenesis Related 1 Like 1) is a protein-coding gene located on chromosome 12q21.2. It belongs to the GLIPR1 family and is predicted to be involved in cellular processes such as apoptosis and cell cycle regulation. The encoded protein shares homology with GLIPR1, a tumor suppressor implicated in prostate cancer. Expression data suggest a role in normal tissue homeostasis and potential involvement in cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Potential tumor suppressor; altered expression may contribute to oncogenesis | Limited; inferred from GLIPR1 family homology (NCBI, OMIM) |
| Breast cancer | Undetermined; expression changes observed in some studies | Preliminary (NCBI Gene) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Prostate | 3.8 | Low |
| Breast | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate) | 4.5 | Low expression |
| MCF-7 (breast) | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200A>G (p.Asn67Ser) | missense | <0.01% | Unknown |
| c.415C>T (p.Arg139Trp) | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function variants reported.
Gain of Function (GOF)
Not established; no confirmed gain-of-function variants reported.
Dominant Negative (DN)
Not established; no evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • negative regulation of apoptotic process (GO:0043066) |
Protein Summary
The GLIPR1L1 protein (UniProt Q6ZMU5) is a 242-amino acid polypeptide with a predicted molecular mass of ~27 kDa. It contains a GLIPR1-like domain and is localized to the cytoplasm. Its function is not fully characterized, but homology suggests involvement in apoptosis regulation and cell cycle control. No crystal structure is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GLIPR1L1 Knockout HEK293 Cell Line | EDJ-KQ11843 | Human | 256710 | Details Get a Quote |
| GLIPR1L1 Knockout HeLa Cell Line | EDJ-KQ59309 | Human | 256710 | Details Get a Quote |
| GLIPR1L1 Knockout A-549 Cell Line | EDJ-KQ67777 | Human | 256710 | Details Get a Quote |
| GLIPR1L1 Knockout HCT 116 Cell Line | EDJ-KQ76158 | Human | 256710 | Details Get a Quote |
