GLG1: Golgi Glycoprotein 1 – A Key Regulator of Cell Adhesion and Tumorigenesis
Comprehensive genomic and proteomic analysis of GLG1, including expression, mutations, and disease associations.
Gene Information Card
| Symbol | GLG1 |
|---|---|
| Full Name | Golgi glycoprotein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 16q23.1 |
| NCBI Gene ID | 27343 ncbi.nlm.nih.gov/gene/27343 |
| Ensembl ID | ENSG00000103197 |
| UniProt ID | Q92896 |
| OMIM ID | 600753 |
| HGNC ID | 4319 |
| Aliases | MG-160, CFR-1, ESL-1, MG160, CFF1 |
Description
GLG1 (Golgi glycoprotein 1) encodes a type I transmembrane protein localized primarily in the Golgi apparatus. It functions as a receptor for fibroblast growth factors (FGFs) and mediates cell adhesion via E-selectin binding. GLG1 is involved in protein trafficking, cell migration, and tumor progression. Alternative names include MG-160 (a sialoglycoprotein) and CFR-1 (cysteine-rich FGF receptor).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression promotes tumor cell adhesion and metastasis via E-selectin binding | COSMIC, ClinVar |
| Colorectal cancer | GLG1 upregulation correlates with poor prognosis and increased metastatic potential | NCBI Gene, PubMed |
| Breast cancer | GLG1 expression associated with invasive phenotype and FGF signaling | UniProt, COSMIC |
| Lung cancer | Altered GLG1 expression linked to tumor growth and migration | COSMIC, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Colon | 15.3 | Medium |
| Breast | 8.9 | Low |
| Liver | 6.2 | Low |
| Brain | 4.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.7 | Cervical cancer cell line |
| A549 | 22.1 | Lung carcinoma cell line |
| MCF7 | 14.5 | Breast cancer cell line |
| HCT116 | 25.3 | Colorectal carcinoma cell line |
| HEK293 | 9.8 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | 0.02% | Unknown functional effect |
| c.567_569del (p.Glu189del) | In-frame deletion | 0.01% | Potential loss of FGF binding |
| c.2101C>T (p.Arg701Trp) | Missense | 0.03% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression and certain missense variants may enhance FGF signaling and cell adhesion.
Dominant Negative (DN)
Not described for GLG1.
View complete mutation data：
Gene Ontology (GO)
| • Golgi apparatus (GO:0005794) | • plasma membrane (GO:0005886) |
| • signaling receptor binding (GO:0005102) | • cell adhesion (GO:0007155) |
| • integral component of membrane (GO:0016021) | • heparin binding (GO:0008201) |
Pathways
• FGF signaling pathway
• E-selectin mediated cell adhesion
• Golgi-to-plasma membrane protein transport
Protein Summary
GLG1 is a 1,179-amino acid transmembrane glycoprotein with a large extracellular domain containing multiple cysteine-rich repeats. It localizes to the Golgi and cell surface, where it binds FGFs and E-selectin. The protein is involved in cell adhesion, migration, and tumor metastasis. Post-translational modifications include N-glycosylation and sialylation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GLG1 Knockout HEK293 Cell Line | EDC10148 | Human | 2734 | Details Get a Quote |
| GLG1 Knockout A-549 Cell Line | EDJ-KQ20175 | Human | 2734 | Details Get a Quote |
| GLG1 Knockout HCT 116 Cell Line | EDJ-KQ20176 | Human | 2734 | Details Get a Quote |
| GLG1 Knockout HeLa Cell Line | EDJ-KQ20177 | Human | 2734 | Details Get a Quote |
