GKN2 (Gastrokine 2)
A stomach-specific protein implicated in gastric mucosal protection and tumor suppression
Gene Information Card
| Symbol | GKN2 |
|---|---|
| Full Name | gastrokine 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p13.3 |
| NCBI Gene ID | 200504 ncbi.nlm.nih.gov/gene/200504 |
| Ensembl ID | ENSG00000162949 |
| UniProt ID | Q86XP6 |
| OMIM ID | 618859 |
| HGNC ID | 24821 |
| Aliases | GDDR, TFIZ1, blottin |
Description
GKN2 (gastrokine 2) is a stomach-specific gene encoding a secreted protein involved in maintaining gastric mucosal integrity and suppressing gastric carcinogenesis. It is frequently downregulated in gastric cancer and Helicobacter pylori infection.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric Cancer | Loss of GKN2 expression contributes to tumor progression and metastasis | Multiple studies show reduced GKN2 mRNA and protein in gastric tumors vs. normal tissue (PMID: 17981184, 21573172) |
| Helicobacter pylori Infection | H. pylori infection downregulates GKN2, impairing mucosal defense | Observed in gastric biopsies (PMID: 19030185) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Stomach | 125.6 | High |
| Duodenum | 2.3 | Low |
| Esophagus | 0.8 | Not detected |
| Colon | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| AGS (gastric adenocarcinoma) | 0.5 | Low expression; often silenced |
| MKN45 (gastric cancer) | 0.3 | Low expression |
| KATO III (gastric cancer) | 0.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | Rare | Likely loss of start codon; predicted loss of function |
| c.217C>T (p.Arg73Trp) | missense | Rare | Unknown significance; not reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Frequent promoter hypermethylation and transcriptional silencing in gastric cancer
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • antimicrobial humoral response (GO:0019730) |
| • response to lipopolysaccharide (GO:0032496) | • innate immune response (GO:0045087) |
Pathways
• Gastric mucosal defense
• Innate immune response to bacteria
Protein Summary
Gastrokine 2 is a 184-amino acid secreted protein expressed predominantly in gastric mucosa. It forms a complex with gastrokine 1 (GKN1) and trefoil factor 1 (TFF1), protecting the gastric epithelium from injury and suppressing inflammation-driven carcinogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GKN2 Knockout HEK293 Cell Line | EDJ-KQ4513 | Human | 200504 | Details Get a Quote |
| GKN2 Knockout A-549 Cell Line | EDJ-KQ27124 | Human | 200504 | Details Get a Quote |
| GKN2 Knockout HeLa Cell Line | EDJ-KQ59008 | Human | 200504 | Details Get a Quote |
| GKN2 Knockout HCT 116 Cell Line | EDJ-KQ75886 | Human | 200504 | Details Get a Quote |
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