GIPC2 Gene - GIPC PDZ Domain Containing Family Member 2 | NCBI, UniProt, OMIM

GIPC2 (GIPC PDZ Domain Containing Family Member 2) is a protein-coding gene located on chromosome 1p31.1. It encodes a member of the GIPC family of PDZ domain-containing proteins, which are involved in trafficking and signaling of G protein-coupled receptors (GPCRs) and other transmembrane proteins. GIPC2 interacts with the C-terminal tail of various receptors, including the insulin-like growth factor 1 receptor (IGF1R) and the dopamine D2 receptor, modulating their internalization and downstream signaling. The gene is expressed in multiple tissues and has been implicated in cancer, particularly through altered expression in breast, lung, and colorectal tumors.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• GPCR signaling (via PDZ domain interactions)

• IGF1R signaling and internalization

• Dopamine D2 receptor trafficking

GIPC2 is a 333-amino acid protein containing a central PDZ domain that mediates interactions with the C-terminal tails of various transmembrane receptors, including GPCRs and receptor tyrosine kinases. It localizes to the plasma membrane and endocytic vesicles, facilitating receptor internalization and recycling. The protein also contains an N-terminal GIPC homology domain and a C-terminal region involved in dimerization. GIPC2 is structurally similar to GIPC1 and GIPC3, but with distinct tissue expression patterns and binding partners.