GGCT Gene - Gamma-Glutamylcyclotransferase
Gene, Function, and Clinical Significance
Gene Information Card
| Symbol | GGCT |
|---|---|
| Full Name | Gamma-glutamylcyclotransferase |
| Gene Type | Protein coding |
| Chromosomal Location | 7p14.3 |
| NCBI Gene ID | 79017 ncbi.nlm.nih.gov/gene/79017 |
| Ensembl ID | ENSG00000106624 |
| UniProt ID | O75223 |
| OMIM ID | 610591 |
| HGNC ID | 24819 |
| Aliases | C7orf24, GGC, GCTG |
Description
The GGCT gene encodes gamma-glutamylcyclotransferase, an enzyme involved in glutathione metabolism. It catalyzes the conversion of gamma-glutamyl amino acids to 5-oxoproline and free amino acids, playing a role in the gamma-glutamyl cycle. GGCT is widely expressed and has been implicated in cancer cell proliferation and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression promotes cell proliferation and resistance to apoptosis | COSMIC, literature |
| Glutathione metabolism disorders | Altered enzyme activity disrupts gamma-glutamyl cycle | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 24.1 | High |
| Liver | 18.5 | High |
| Brain | 12.3 | Medium |
| Heart | 9.8 | Medium |
| Lung | 7.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 28.5 | Cervical cancer cell line |
| MCF7 | 22.1 | Breast cancer cell line |
| A549 | 19.4 | Lung cancer cell line |
| HEK293 | 15.6 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.100C>T) predicted to cause loss of enzyme activity.
Gain of Function (GOF)
Not reported in COSMIC or ClinVar.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • gamma-glutamylcyclotransferase activity | • glutathione metabolic process |
| • cytoplasm |
Pathways
• Glutathione metabolism
Protein Summary
Gamma-glutamylcyclotransferase is a 188-amino acid protein localized in the cytoplasm. It catalyzes the formation of 5-oxoproline from gamma-glutamyl amino acids, a key step in glutathione recycling. Overexpression in cancers suggests a role in redox homeostasis and tumor growth.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GGCT Knockout HEK293 Cell Line | EDJ-KQ12841 | Human | 79017 | Details Get a Quote |
| GGCT Knockout A-549 Cell Line | EDJ-KQ43250 | Human | 79017 | Details Get a Quote |
| GGCT Knockout HCT 116 Cell Line | EDJ-KQ43252 | Human | 79017 | Details Get a Quote |
| GGCT Knockout HeLa Cell Line | EDJ-KQ43253 | Human | 79017 | Details Get a Quote |
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