GBP2: Guanylate Binding Protein 2
A key interferon-inducible GTPase involved in host defense, inflammation, and cancer biology.
Gene Information Card
| Symbol | GBP2 |
|---|---|
| Full Name | Guanylate Binding Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p22.2 |
| NCBI Gene ID | 2634 ncbi.nlm.nih.gov/gene/2634 |
| Ensembl ID | ENSG00000162645 |
| UniProt ID | P32456 |
| OMIM ID | 600412 |
| HGNC ID | 4184 |
| Aliases | GBP-2, MxA, MxB, guanylate-binding protein 2, interferon-inducible |
Description
GBP2 (Guanylate Binding Protein 2) is an interferon-inducible member of the dynamin superfamily of large GTPases. It is involved in innate immune responses against intracellular pathogens, regulation of inflammation, and modulation of cell proliferation. GBP2 exhibits antiviral and antibacterial activity, and its expression is upregulated by type I and type II interferons. The protein localizes to the cytoplasm and can associate with membranes, contributing to vesicle trafficking and pathogen restriction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Infectious diseases (e.g., influenza, HIV, Mycobacterium tuberculosis) | GBP2 restricts viral and bacterial replication through GTPase-dependent mechanisms and inflammasome activation. | NCBI Gene, UniProt |
| Cancer (e.g., breast, colorectal, lung) | GBP2 expression is altered in various cancers; it may act as a tumor suppressor or promoter depending on context, influencing cell migration and immune evasion. | COSMIC, NCBI Gene |
| Inflammatory disorders | GBP2 modulates NLRP3 inflammasome assembly and IL-1β secretion, contributing to chronic inflammation. | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Blood | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Lung | 8.7 | Medium |
| Liver | 6.3 | Low |
| Heart | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.0 | High expression |
| A549 | 12.3 | High expression |
| HepG2 | 8.5 | Medium expression |
| K562 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Cys) | Missense | <0.01% | Unknown functional effect |
| c.1246G>A (p.Val416Met) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activity | • GTP binding |
| • interferon-gamma-mediated signaling pathway | • innate immune response |
| • defense response to virus | • inflammasome complex assembly |
| • cytoplasm | • membrane |
Pathways
• Interferon gamma signaling (Reactome: R-HSA-877300)
• Innate Immune System (Reactome: R-HSA-168249)
• NLRP3 inflammasome pathway
Protein Summary
GBP2 is a 67 kDa interferon-inducible GTPase that belongs to the dynamin superfamily. It hydrolyzes GTP to GDP and GMP, and is involved in antimicrobial and antiviral immunity. The protein promotes inflammasome activation, vesicle trafficking, and pathogen restriction. It is expressed in immune tissues and upregulated by interferons. Structural studies reveal a large GTPase domain and a helical bundle that mediates membrane association.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GBP2 Knockout HEK293 Cell Line | EDJ-KQ3198 | Human | 2634 | Details Get a Quote |
| GBP2 Knockout A-549 Cell Line | EDJ-KQ26010 | Human | 2634 | Details Get a Quote |
| GBP2 Knockout HeLa Cell Line | EDJ-KQ26012 | Human | 2634 | Details Get a Quote |
| GBP2 Knockout HCT 116 Cell Line | EDJ-KQ70278 | Human | 2634 | Details Get a Quote |
