GATAD1
GATA Zinc Finger Domain Containing 1
Gene Information Card
| Symbol | GATAD1 |
|---|---|
| Full Name | GATA zinc finger domain containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q21.13 |
| NCBI Gene ID | 57798 ncbi.nlm.nih.gov/gene/57798 |
| Ensembl ID | ENSG00000105963 |
| UniProt ID | Q8WUU5 |
| OMIM ID | 614516 |
| HGNC ID | 29937 |
| Aliases | ODAG, FLJ11273, MGC131831 |
Description
GATAD1 (GATA zinc finger domain containing 1) encodes a protein that contains a GATA-type zinc finger domain, which is involved in DNA binding and transcriptional regulation. The protein is thought to play a role in chromatin remodeling and gene expression control. GATAD1 is ubiquitously expressed and has been implicated in cellular processes such as proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Heart | 6.3 | Low |
| Liver | 4.1 | Low |
| Kidney | 5.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.0 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical carcinoma cells |
| K562 | 7.5 | Leukemia cells |
| HepG2 | 6.2 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • regulation of transcription, DNA-templated (GO:0006355) |
Pathways
• No specific pathways curated
Protein Summary
The GATAD1 protein (UniProt Q8WUU5) is 305 amino acids long and contains a single GATA-type zinc finger domain. It localizes to the nucleus and is involved in transcriptional regulation. The protein is expressed in multiple tissues and may function as a chromatin-associated factor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GATAD1 Knockout HEK293 Cell Line | EDJ-KQ1027 | Human | 57798 | Details Get a Quote |
| GATAD1 Knockout A-549 Cell Line | EDJ-KQ20126 | Human | 57798 | Details Get a Quote |
| GATAD1 Knockout HCT 116 Cell Line | EDJ-KQ20127 | Human | 57798 | Details Get a Quote |
| GATAD1 Knockout HeLa Cell Line | EDJ-KQ18788 | Human | 57798 | Details Get a Quote |
| GATAD1 Overexpression K-562 Stable Cell Line | EDC01490 | Human | 57798 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
