GAS6: Growth Arrest Specific 6 Gene
A key ligand in TAM receptor tyrosine kinase signaling, involved in cell survival, proliferation, and immune regulation.
Gene Information Card
| Symbol | GAS6 |
|---|---|
| Full Name | Growth Arrest Specific 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q34 |
| NCBI Gene ID | 2621 ncbi.nlm.nih.gov/gene/2621 |
| Ensembl ID | ENSG00000183087 |
| UniProt ID | Q14393 |
| OMIM ID | 600441 |
| HGNC ID | 4168 |
| Aliases | AXLLG, Gas-6, growth arrest-specific protein 6 |
Description
GAS6 (Growth Arrest Specific 6) encodes a vitamin K-dependent protein that acts as a ligand for TAM receptor tyrosine kinases (TYRO3, AXL, MERTK). It is involved in cell survival, proliferation, migration, and phagocytosis. GAS6 is structurally similar to protein S but lacks anticoagulant activity. It plays roles in cancer progression, autoimmune diseases, thrombosis, and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | GAS6 deficiency impairs clearance of apoptotic cells via TAM receptors, leading to autoantigen exposure and immune activation. | ClinVar, OMIM |
| Venous thromboembolism | GAS6 variants may alter plasma levels and affect coagulation regulation. | ClinVar, NCBI |
| Non-small cell lung cancer | GAS6 overexpression activates AXL signaling, promoting tumor cell survival and metastasis. | COSMIC, NCBI |
| Glioblastoma | GAS6-AXL signaling contributes to therapy resistance and tumor invasion. | COSMIC, NCBI |
| Acute ischemic stroke | Elevated GAS6 levels associated with poor outcome and larger infarct size. | ClinVar, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 11.2 | Medium |
| Lung | 8.5 | Medium |
| Liver | 6.3 | Low |
| Kidney | 9.1 | Medium |
| Brain | 4.7 | Low |
| Spleen | 7.8 | Medium |
| Testis | 3.2 | Low |
| Thyroid | 10.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.5 | Embryonic kidney cells |
| A549 | 9.8 | Lung adenocarcinoma |
| MCF7 | 6.1 | Breast cancer |
| HepG2 | 7.3 | Hepatocellular carcinoma |
| U87MG | 14.2 | Glioblastoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1528G>A (p.Glu510Lys) | Missense | 0.01% | Alters ligand-receptor binding affinity |
| c.834C>T (p.Arg278Trp) | Missense | 0.005% | Reduced protein stability |
| c.1129_1131del (p.Phe377del) | Deletion | 0.002% | Loss of function in TAM signaling |
Mutation functional classification
Loss of Function (LOF)
Mutations that reduce GAS6 secretion or receptor binding, impairing apoptotic cell clearance and immune homeostasis.
Gain of Function (GOF)
Overexpression or activating mutations that enhance AXL signaling, promoting cancer cell survival and metastasis.
Dominant Negative (DN)
Not well documented; rare variants may interfere with wild-type GAS6 function in dimerization.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TAM receptor signaling pathway (Reactome: R-HSA-8939211)
• Apoptosis and survival (KEGG: hsa04210)
• Phagocytosis (Reactome: R-HSA-2029480)
• Vitamin K metabolism (Reactome: R-HSA-6803544)
Protein Summary
GAS6 is a 75 kDa vitamin K-dependent glycoprotein composed of an N-terminal Gla domain, four EGF-like domains, and a C-terminal sex hormone-binding globulin (SHBG) domain. The Gla domain mediates binding to phosphatidylserine on apoptotic cells, while the SHBG domain binds TAM receptors. GAS6 is secreted and circulates in plasma. It is a key regulator of efferocytosis, cell survival, and immune tolerance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GAS6 Knockout HEK293 Cell Line | EDJ-KQ3061 | Human | 2621 | Details Get a Quote |
| GAS6 Knockout A-549 Cell Line | EDJ-KQ25695 | Human | 2621 | Details Get a Quote |
| GAS6 Knockout HCT 116 Cell Line | EDJ-KQ25696 | Human | 2621 | Details Get a Quote |
| GAS6 Knockout HeLa Cell Line | EDJ-KQ25697 | Human | 2621 | Details Get a Quote |
