GALNT10
Polypeptide N-Acetylgalactosaminyltransferase 10
Gene Information Card
| Symbol | GALNT10 |
|---|---|
| Full Name | Polypeptide N-acetylgalactosaminyltransferase 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q33.2 |
| NCBI Gene ID | 55568 ncbi.nlm.nih.gov/gene/55568 |
| Ensembl ID | ENSG00000164530 |
| UniProt ID | Q86SF2 |
| OMIM ID | 609220 |
| HGNC ID | 4128 |
| Aliases | GalNAc-T10, pp-GalNAc-T10, GALNACT10 |
Description
GALNT10 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family. This enzyme initiates mucin-type O-linked glycosylation by transferring N-acetylgalactosamine (GalNAc) to serine or threonine residues on target proteins. GALNT10 is involved in the biosynthesis of O-glycans and plays roles in cell adhesion, signaling, and tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered O-glycosylation of mucins and cell surface proteins may promote tumor cell invasion and metastasis. | COSMIC; PMID: 25686134 |
| Pancreatic cancer | Upregulation of GALNT10 correlates with aberrant glycosylation and poor prognosis. | COSMIC; PMID: 28287077 |
| Breast cancer | Differential expression of GALNT10 affects O-glycan profiles and may influence tumor growth. | COSMIC; PMID: 24884766 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 10.2 | Medium |
| Kidney | 8.5 | Medium |
| Colon | 7.1 | Medium |
| Pancreas | 6.8 | Medium |
| Breast | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 12.5 | Hepatocellular carcinoma cell line |
| MCF7 | 5.2 | Breast cancer cell line |
| PANC-1 | 9.8 | Pancreatic cancer cell line |
| HT-29 | 8.1 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | 0.01% | Unknown functional impact; reported in COSMIC |
| c.567G>A (p.Val189Ile) | Missense | 0.005% | COSMIC; no known disease association |
| c.890_891insA | Frameshift | <0.001% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants predicted to truncate the protein and abolish enzymatic activity.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • polypeptide N-acetylgalactosaminyltransferase activity (GO:0004653) | • protein O-linked glycosylation (GO:0006493) |
| • integral component of membrane (GO:0016021) | • Golgi apparatus (GO:0005794) |
Pathways
• O-linked glycosylation of mucins (Reactome: R-HSA-913709)
• Formation of O-glycan core 1 (Reactome: R-HSA-975577)
Protein Summary
GALNT10 is a type II transmembrane protein localized to the Golgi apparatus. It catalyzes the initial step of mucin-type O-glycosylation, transferring GalNAc from UDP-GalNAc to serine/threonine residues. The enzyme has a catalytic domain and a lectin domain that may facilitate substrate recognition. GALNT10 is widely expressed in epithelial tissues and is implicated in cancer-associated glycosylation changes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GALNT10 Knockout HEK293 Cell Line | EDJ-KQ13555 | Human | 55568 | Details Get a Quote |
| GALNT10 Knockout A-549 Cell Line | EDJ-KQ43179 | Human | 55568 | Details Get a Quote |
| GALNT10 Knockout HCT 116 Cell Line | EDJ-KQ43180 | Human | 55568 | Details Get a Quote |
| GALNT10 Knockout HeLa Cell Line | EDJ-KQ43181 | Human | 55568 | Details Get a Quote |
