GAL3ST3
Galactose-3-O-Sulfotransferase 3
Gene Information Card
| Symbol | GAL3ST3 |
|---|---|
| Full Name | Galactose-3-O-Sulfotransferase 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.2 |
| NCBI Gene ID | 117246 ncbi.nlm.nih.gov/gene/117246 |
| Ensembl ID | ENSG00000137710 |
| UniProt ID | Q96A11 |
| OMIM ID | 608234 |
| HGNC ID | 24138 |
| Aliases | GAL3ST-3, GAL3ST3A, GAL3ST3B |
Description
GAL3ST3 encodes a member of the galactose-3-O-sulfotransferase family. This enzyme catalyzes the transfer of sulfate to galactose residues in glycoproteins and glycolipids, contributing to the biosynthesis of sulfated glycoconjugates. It is involved in the modification of glycosaminoglycans and plays a role in cell adhesion and signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered sulfation patterns may affect tumor cell adhesion and metastasis. | COSMIC; PMID: 23481259 |
| Breast Cancer | Dysregulated expression linked to changes in sulfated glycans. | NCBI Gene; PMID: 25691885 |
| Hepatocellular Carcinoma | Upregulation associated with poor prognosis. | UniProt; PMID: 27864331 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Breast | 8.3 | Low |
| Liver | 6.7 | Low |
| Kidney | 5.2 | Low |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 | 15.2 | Colorectal carcinoma line |
| MCF7 | 9.8 | Breast adenocarcinoma line |
| HepG2 | 7.4 | Hepatocellular carcinoma line |
| HEK293 | 3.1 | Embryonic kidney line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | missense | <0.01% | Unknown functional impact |
| c.521G>A (p.Arg174His) | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • galactose 3-O-sulfotransferase activity | • sulfotransferase activity |
| • Golgi membrane | • protein sulfation |
| • carbohydrate sulfation |
Pathways
• Glycosaminoglycan biosynthesis - keratan sulfate
• Sulfur metabolism
Protein Summary
GAL3ST3 is a 423-amino acid type II transmembrane protein localized to the Golgi apparatus. It transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the 3-hydroxyl group of galactose in glycoconjugates. The protein is involved in the synthesis of sulfated keratan sulfate and other sulfated glycans, influencing cell-cell interactions and extracellular matrix composition.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GAL3ST3 Knockout HEK293 Cell Line | EDJ-KQ10505 | Human | 89792 | Details Get a Quote |
| GAL3ST3 Knockout HeLa Cell Line | EDJ-KQ57739 | Human | 89792 | Details Get a Quote |
| GAL3ST3 Knockout A-549 Cell Line | EDJ-KQ66235 | Human | 89792 | Details Get a Quote |
| GAL3ST3 Knockout HCT 116 Cell Line | EDJ-KQ74656 | Human | 89792 | Details Get a Quote |
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