GAL3ST2
Galactose-3-O-Sulfotransferase 2
Gene Information Card
| Symbol | GAL3ST2 |
|---|---|
| Full Name | Galactose-3-O-Sulfotransferase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 64090 ncbi.nlm.nih.gov/gene/64090 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | Q9H3R5 |
| OMIM ID | 608151 |
| HGNC ID | 24138 |
| Aliases | GAL3ST-2, GP3ST, Gal3ST2 |
Description
GAL3ST2 encodes galactose-3-O-sulfotransferase 2, an enzyme that catalyzes the transfer of sulfate to galactose residues in glycoproteins and glycolipids. This sulfation is critical for the biosynthesis of sulfated glycosaminoglycans and plays roles in cell adhesion, signaling, and extracellular matrix interactions. The gene is expressed in various tissues and is implicated in cancer progression and immune modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered sulfation of cell surface glycans may promote tumor growth and metastasis | COSMIC, ClinVar |
| Breast Cancer | Dysregulated GAL3ST2 expression linked to poor prognosis and invasive phenotype | NCBI Gene, PubMed |
| Ovarian Cancer | Upregulation associated with chemoresistance and metastatic spread | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Breast | 8.3 | Low |
| Ovary | 15.2 | Medium |
| Liver | 5.1 | Low |
| Lung | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 14.0 | Moderate expression |
| HT-29 (colorectal cancer) | 18.5 | High expression |
| OVCAR-3 (ovarian cancer) | 20.1 | High expression |
| HepG2 (liver cancer) | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101G>A (p.Arg34His) | Missense | <0.01% | Unknown functional impact |
| c.452C>T (p.Pro151Leu) | Missense | <0.01% | Predicted benign |
| c.788_789insA | Frameshift | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.788_789insA) likely result in truncated, non-functional protein.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • sulfotransferase activity | • galactose 3-O-sulfation |
| • glycosaminoglycan biosynthetic process | • Golgi membrane |
Pathways
• Glycosaminoglycan biosynthesis - heparan sulfate / heparin
• Sulfur metabolism
• Metabolism of carbohydrates
Protein Summary
Galactose-3-O-sulfotransferase 2 is a Golgi-resident enzyme that transfers sulfate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the 3-hydroxyl group of galactose in glycoconjugates. The 423-amino acid protein contains a sulfotransferase domain and is essential for the synthesis of sulfated glycans such as keratan sulfate. Its activity influences cell-cell recognition and tumor microenvironment remodeling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GAL3ST2 Knockout HEK293 Cell Line | EDJ-KQ13554 | Human | 64090 | Details Get a Quote |
| GAL3ST2 Knockout HeLa Cell Line | EDJ-KQ57019 | Human | 64090 | Details Get a Quote |
| GAL3ST2 Knockout A-549 Cell Line | EDJ-KQ65525 | Human | 64090 | Details Get a Quote |
| GAL3ST2 Knockout HCT 116 Cell Line | EDJ-KQ73960 | Human | 64090 | Details Get a Quote |
