GAGE7 Gene - G Antigen 7
Cancer/Testis Antigen Family Member GAGE7
Gene Information Card
| Symbol | GAGE7 |
|---|---|
| Full Name | G antigen 7 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp11.23 |
| NCBI Gene ID | 2579 ncbi.nlm.nih.gov/gene/2579 |
| Ensembl ID | ENSG00000146707 |
| UniProt ID | Q13067 |
| OMIM ID | 300598 |
| HGNC ID | 4100 |
| Aliases | CT4.7, GAGE-7, GAGE7B |
Description
GAGE7 is a member of the GAGE gene family, which encodes cancer/testis antigens (CTAs). These proteins are normally expressed only in testis germ cells but are aberrantly expressed in various cancers, making them potential targets for immunotherapy and biomarkers. GAGE7 is located on chromosome Xp11.23 and is part of a tandemly repeated gene cluster.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | Overexpression of GAGE7 in melanoma cells may contribute to immune evasion by modulating antigen presentation. | NCBI Gene, PubMed: 10647931 |
| Non-small cell lung cancer | GAGE7 mRNA is upregulated in NSCLC tissues and associated with poor prognosis. | PubMed: 19030170 |
| Breast cancer | GAGE7 expression detected in breast tumor samples, linked to hormone receptor status. | PubMed: 15604238 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not expressed (nTPM data not available for GAGE7 in GTEx) |
| Skin | 0.0 | Not expressed |
| Lung | 0.0 | Not expressed |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | 0.0 | No detectable expression in standard RNA-seq |
| A375 (melanoma) | 0.0 | Expression may be induced under specific conditions |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • molecular_function (GO:0003674) |
Pathways
• No specific pathway annotations in KEGG or Reactome for GAGE7.
Protein Summary
GAGE7 is a 117-amino acid protein belonging to the GAGE family. It is localized to the cytoplasm and may be secreted. Its exact molecular function is unknown, but it is thought to play a role in cell cycle regulation and immune recognition in cancer cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GAGE7 Knockout HEK293 Cell Line | EDJ-KQ4668 | Human | 2579 | Details Get a Quote |
| GAGE7 Knockout HCT 116 Cell Line | EDJ-KQ26116 | Human | 2579 | Details Get a Quote |
| GAGE7 Knockout A-549 Cell Line | EDJ-KQ27351 | Human | 2579 | Details Get a Quote |
| GAGE7 Knockout HeLa Cell Line | EDJ-KQ27352 | Human | 2579 | Details Get a Quote |
