G0S2
G0/G1 Switch 2
Gene Information Card
| Symbol | G0S2 |
|---|---|
| Full Name | G0/G1 Switch 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q25.1 |
| NCBI Gene ID | 50486 ncbi.nlm.nih.gov/gene/50486 |
| Ensembl ID | ENSG00000143149 |
| UniProt ID | P27469 |
| OMIM ID | 614523 |
| HGNC ID | 30279 |
| Aliases | G0S2A, G0S2B |
Description
The G0S2 gene encodes a small protein involved in cell cycle regulation, particularly the G0/G1 transition. It is highly expressed in adipose tissue and plays a role in adipogenesis and lipid metabolism. G0S2 also functions as a regulator of apoptosis and has been implicated in various cancers, where its expression is often dysregulated.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | G0S2 regulates adipogenesis and lipid storage; altered expression may contribute to adipose tissue dysfunction. | PMID: 22960657 |
| Non-small cell lung cancer | G0S2 is frequently hypermethylated and silenced, promoting cell proliferation. | PMID: 23382210 |
| Acute myeloid leukemia | G0S2 expression is reduced, associated with poor prognosis and differentiation block. | PMID: 24740811 |
| Breast cancer | G0S2 downregulation correlates with tumor progression and metastasis. | PMID: 25636847 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 112.3 | High |
| Liver | 8.5 | Medium |
| Lung | 3.2 | Low |
| Bone marrow | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| 3T3-L1 (adipocyte) | 85.0 | High expression during differentiation |
| A549 (lung cancer) | 2.5 | Low expression due to methylation |
| MCF7 (breast cancer) | 4.0 | Reduced compared to normal |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.85C>T | nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein; epigenetic silencing via promoter methylation.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • cell cycle (GO:0007049) | • apoptotic process (GO:0006915) |
| • response to insulin (GO:0032868) | • fat cell differentiation (GO:0045444) |
Pathways
• Adipogenesis
• PPAR signaling pathway
• p53 signaling pathway
Protein Summary
G0S2 is a 103-amino acid protein localized to the mitochondria and endoplasmic reticulum. It interacts with BCL2 to promote apoptosis and regulates lipid droplet formation by binding to ATGL. The protein is a key mediator of cell cycle arrest and metabolic homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| G0S2 Knockout HEK293 Cell Line | EDJ-KQ10754 | Human | 50486 | Details Get a Quote |
| G0S2 Knockout A-549 Cell Line | EDJ-KQ38352 | Human | 50486 | Details Get a Quote |
| G0S2 Knockout HeLa Cell Line | EDJ-KQ38353 | Human | 50486 | Details Get a Quote |
| G0S2 Knockout HCT 116 Cell Line | EDJ-KQ73101 | Human | 50486 | Details Get a Quote |
