FZD7 Gene - Frizzled Class Receptor 7
Wnt Signaling Pathway Receptor in Development and Cancer
Gene Information Card
| Symbol | FZD7 |
|---|---|
| Full Name | Frizzled Class Receptor 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 8324 ncbi.nlm.nih.gov/gene/8324 |
| Ensembl ID | ENSG00000155760 |
| UniProt ID | O75084 |
| OMIM ID | 603410 |
| HGNC ID | 4042 |
| Aliases | Fz-7, Frizzled-7, FZD7_HUMAN |
Description
FZD7 encodes a member of the Frizzled family of seven-transmembrane domain receptors that function as receptors for Wnt signaling proteins. FZD7 plays a critical role in embryonic development, cell polarity, and tissue homeostasis. It is frequently overexpressed in various cancers and is implicated in cancer stem cell maintenance and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | FZD7 overexpression activates canonical Wnt/β-catenin signaling, promoting tumor growth and invasion. | High expression correlates with poor prognosis (PMID: 25944712) |
| Hepatocellular Carcinoma | FZD7 upregulation enhances Wnt/β-catenin signaling, contributing to cancer stem cell self-renewal. | Overexpression in HCC tissues vs. normal liver (PMID: 20010866) |
| Breast Cancer | FZD7 mediates Wnt signaling to promote epithelial-mesenchymal transition (EMT) and metastasis. | High FZD7 expression in triple-negative breast cancer (PMID: 25016929) |
| Gastric Cancer | FZD7 activates β-catenin/TCF transcription, driving proliferation and invasion. | FZD7 knockdown reduces tumor growth in xenografts (PMID: 23934182) |
| Ovarian Cancer | FZD7 overexpression correlates with chemoresistance and poor survival. | Upregulated in ovarian cancer cell lines (PMID: 21804532) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Kidney | 8.2 | Medium |
| Liver | 6.1 | Low |
| Lung | 5.4 | Low |
| Breast | 4.8 | Low |
| Colon | 3.9 | Low |
| Brain | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 (Colorectal) | 15.3 | High expression |
| HepG2 (Liver) | 12.1 | High expression |
| MCF7 (Breast) | 8.7 | Medium expression |
| A549 (Lung) | 6.4 | Low expression |
| SKOV3 (Ovarian) | 11.0 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015G>A (p.Gly339Arg) | Missense | <0.1% | Unknown functional impact |
| c.1246C>T (p.Arg416Trp) | Missense | <0.1% | Unknown functional impact |
| c.1573C>T (p.Arg525Trp) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in FZD7.
Gain of Function (GOF)
FZD7 overexpression is considered a gain-of-function mechanism in cancer, but no activating point mutations are documented.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Hippo signaling pathway (KEGG: hsa04390)
• Signaling pathways regulating pluripotency of stem cells (KEGG: hsa04550)
• Breast cancer pathway (KEGG: hsa05224)
• Hepatocellular carcinoma pathway (KEGG: hsa05225)
Protein Summary
FZD7 is a 574-amino acid seven-transmembrane receptor that binds Wnt ligands, particularly Wnt3a and Wnt5a. It activates both canonical (β-catenin-dependent) and non-canonical Wnt signaling pathways. The protein contains a cysteine-rich domain (CRD) in its extracellular N-terminus essential for Wnt binding. FZD7 is highly conserved across species and is a key regulator of cell proliferation, differentiation, and migration. Its overexpression in multiple cancers makes it a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FZD7 Knockout HEK293 Cell Line | EDJ-KQ308 | Human | 8324 | Details Get a Quote |
| FZD7 Knockout A-549 Cell Line | EDJ-KQ18440 | Human | 8324 | Details Get a Quote |
| FZD7 Knockout HCT 116 Cell Line | EDJ-KQ18441 | Human | 8324 | Details Get a Quote |
| FZD7 Knockout HeLa Cell Line | EDJ-KQ18442 | Human | 8324 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
