FZD5 (Frizzled Class Receptor 5)
WNT Signaling Receptor in Development and Cancer
Gene Information Card
| Symbol | FZD5 |
|---|---|
| Full Name | Frizzled Class Receptor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.3 |
| NCBI Gene ID | 7855 ncbi.nlm.nih.gov/gene/7855 |
| Ensembl ID | ENSG00000163251 |
| UniProt ID | Q13467 |
| OMIM ID | 601723 |
| HGNC ID | 4042 |
| Aliases | Fz-5, Fz5, HFZ5 |
Description
FZD5 encodes a member of the frizzled family of seven-transmembrane domain receptors that function as receptors for WNT signaling proteins. FZD5 specifically binds WNT5A and WNT3A, activating canonical (β-catenin-dependent) and non-canonical pathways. It plays critical roles in embryonic development, cell polarity, and tissue homeostasis. Aberrant FZD5 expression and mutations are implicated in colorectal cancer, hepatocellular carcinoma, and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | FZD5 overexpression activates β-catenin/TCF transcription, promoting cell proliferation | PMID: 19029980 |
| Hepatocellular Carcinoma | FZD5 upregulation correlates with WNT/β-catenin pathway activation and poor prognosis | PMID: 21252315 |
| Retinoblastoma | FZD5 mutations (e.g., p.Gly488Glu) alter WNT signaling in tumorigenesis | PMID: 25231345 |
| Ovarian Cancer | FZD5 amplification and overexpression drive tumor growth via WNT signaling | PMID: 21502563 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 6.2 | Low |
| Colon | 15.8 | Medium |
| Liver | 12.1 | Medium |
| Kidney | 8.5 | Low |
| Lung | 9.3 | Low |
| Ovary | 14.5 | Medium |
| Testis | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 (Colorectal) | 18.5 | High expression; WNT-dependent |
| HepG2 (Liver) | 14.2 | Medium expression |
| A549 (Lung) | 7.8 | Low expression |
| SKOV3 (Ovarian) | 16.3 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1463G>A (p.Gly488Glu) | Missense | <1% | Alters WNT binding affinity; associated with retinoblastoma |
| c.1120C>T (p.Arg374Trp) | Missense | <1% | Unknown functional effect |
| Amplification | Copy number gain | 5-10% in ovarian cancer | Increases FZD5 expression; drives WNT signaling |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Amplification and overexpression in cancers lead to constitutive WNT signaling.
Dominant Negative (DN)
Not described for FZD5.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • WNT-protein binding |
| • WNT signaling pathway | • canonical WNT signaling pathway |
| • cell surface receptor signaling pathway | • cell-cell signaling |
| • embryonic development | • cell polarity |
Pathways
• WNT signaling pathway (KEGG: hsa04310)
• WNT/β-catenin signaling (Reactome: R-HSA-201681)
• Non-canonical WNT/PCP signaling (Reactome: R-HSA-4086400)
• Planar cell polarity pathway (Reactome: R-HSA-4086398)
Protein Summary
Frizzled-5 (FZD5) is a 585-amino acid seven-transmembrane receptor with an N-terminal cysteine-rich domain (CRD) essential for WNT ligand binding. It localizes to the plasma membrane and transduces signals via Dishevelled (DVL) to β-catenin stabilization or planar cell polarity pathways. Post-translational modifications include N-glycosylation and palmitoylation. FZD5 is highly expressed in testis, colon, and liver, and its dysregulation contributes to oncogenic WNT signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FZD5 Knockout HEK293 Cell Line | EDJ-KQ306 | Human | 7855 | Details Get a Quote |
| FZD5 Knockout HCT 116 Cell Line | EDJ-KQ17967 | Human | 7855 | Details Get a Quote |
| FZD5 Knockout A-549 Cell Line | EDJ-KQ18434 | Human | 7855 | Details Get a Quote |
| FZD5 Knockout HeLa Cell Line | EDJ-KQ18436 | Human | 7855 | Details Get a Quote |
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