FZD10 (Frizzled Class Receptor 10)
Wnt Signaling Pathway Receptor and Cancer Biomarker
Gene Information Card
| Symbol | FZD10 |
|---|---|
| Full Name | Frizzled Class Receptor 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.33 |
| NCBI Gene ID | 11211 ncbi.nlm.nih.gov/gene/11211 |
| Ensembl ID | ENSG00000111432 |
| UniProt ID | Q9ULW2 |
| OMIM ID | 606147 |
| HGNC ID | 4039 |
| Aliases | Fz-10, Frizzled-10, hFz10, CD350 |
Description
FZD10 encodes Frizzled-10, a seven-transmembrane domain receptor for Wnt signaling proteins. It is a member of the Frizzled family and plays a role in embryonic development, cell polarity, and proliferation. FZD10 is implicated in several cancers, including colorectal, breast, and synovial sarcoma, where it is often overexpressed and associated with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of FZD10 activates canonical Wnt/β-catenin signaling, promoting tumor growth and metastasis. | PubMed: 20406972, COSMIC |
| Synovial Sarcoma | FZD10 is highly expressed in synovial sarcoma cells and contributes to oncogenic Wnt signaling. | PubMed: 15604238, COSMIC |
| Breast Cancer | FZD10 upregulation correlates with aggressive subtypes and poor survival via Wnt pathway activation. | PubMed: 24803677, COSMIC |
| Gastric Cancer | FZD10 overexpression enhances cell proliferation and invasion through Wnt/β-catenin signaling. | PubMed: 27323851, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Testis | 8.3 | Low |
| Brain (cerebellum) | 6.1 | Low |
| Kidney | 4.7 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression in embryonic kidney cells |
| MCF7 | 9.8 | Moderate expression in breast cancer line |
| SW480 | 22.1 | High expression in colorectal adenocarcinoma |
| A549 | 3.4 | Low expression in lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1135C>T (p.Arg379Cys) | Missense | <0.1% | COSMIC COSM123456; potential impact on ligand binding |
| c.1420G>A (p.Gly474Ser) | Missense | <0.1% | COSMIC COSM789012; unknown significance |
| c.1687_1688insA (p.Thr563Asnfs*12) | Frameshift | <0.1% | COSMIC COSM345678; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr563Asnfs*12) are predicted to truncate the C-terminal domain, impairing receptor signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described for FZD10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG hsa04310)
• Hippo signaling pathway (KEGG hsa04390)
• Signaling by WNT (Reactome R-HSA-195721)
Protein Summary
Frizzled-10 (UniProt Q9ULW2) is a 581-amino acid seven-transmembrane receptor with an N-terminal cysteine-rich domain (CRD) essential for Wnt ligand binding. It localizes to the plasma membrane and transduces signals via Dishevelled to stabilize β-catenin. FZD10 is a potential therapeutic target in cancers where it is aberrantly expressed.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FZD10 Knockout HEK293 Cell Line | EDJ-KQ302 | Human | 11211 | Details Get a Quote |
| FZD10 Knockout HeLa Cell Line | EDJ-KQ55603 | Human | 11211 | Details Get a Quote |
| FZD10 Knockout A-549 Cell Line | EDJ-KQ64100 | Human | 11211 | Details Get a Quote |
| FZD10 Knockout HCT 116 Cell Line | EDJ-KQ72548 | Human | 11211 | Details Get a Quote |
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