FXYD3
FXYD Domain Containing Ion Transport Regulator 3
Gene Information Card
| Symbol | FXYD3 |
|---|---|
| Full Name | FXYD domain containing ion transport regulator 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.12 |
| NCBI Gene ID | 5349 ncbi.nlm.nih.gov/gene/5349 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | Q14802 |
| OMIM ID | 604535 |
| HGNC ID | 4026 |
| Aliases | MAT8, PLML |
Description
FXYD3 (FXYD domain containing ion transport regulator 3), also known as MAT8, is a member of the FXYD family of small ion transport regulators. It modulates the activity of Na+/K+-ATPase and is implicated in cell adhesion, migration, and cancer progression. FXYD3 is overexpressed in several carcinomas, including breast, lung, and pancreatic cancers, and is considered a potential biomarker.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast carcinoma | Overexpression of FXYD3 correlates with poor prognosis and may promote cell migration | PMID: 19029981 |
| Non-small cell lung cancer | Upregulation associated with tumor progression and metastasis | PMID: 21804532 |
| Pancreatic ductal adenocarcinoma | FXYD3 overexpression linked to aggressive phenotype and shorter survival | PMID: 23359680 |
| Gastric cancer | Increased expression associated with lymph node metastasis | PMID: 25636567 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 | Medium |
| Lung | 8.3 | Low |
| Pancreas | 15.2 | Medium |
| Stomach | 9.7 | Low |
| Colon | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.4 | High expression |
| A549 (lung cancer) | 11.2 | Moderate expression |
| PANC-1 (pancreatic cancer) | 22.0 | High expression |
| HeLa (cervical cancer) | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.74C>T | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in FXYD3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression is primarily transcriptional.
Dominant Negative (DN)
No dominant-negative mutations described for FXYD3.
View complete mutation data：
Gene Ontology (GO)
| • ion channel regulator activity | • plasma membrane |
| • integral component of membrane | • regulation of ion transmembrane transport |
| • cell adhesion |
Pathways
• Na+/K+-ATPase regulation
• Ion transport by P-type ATPases
Protein Summary
FXYD3 is a 87-amino acid single-pass transmembrane protein belonging to the FXYD family. It contains a conserved FXYD motif and modulates Na+/K+-ATPase activity by altering its affinity for ions. The protein is localized to the plasma membrane and plays roles in cell adhesion and migration. Overexpression in multiple cancers suggests a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FXYD3 Knockout HEK293 Cell Line | EDJ-KQ50518 | Human | 5349 | Details Get a Quote |
| FXYD3 Knockout HeLa Cell Line | EDJ-KQ54158 | Human | 5349 | Details Get a Quote |
| FXYD3 Knockout A-549 Cell Line | EDJ-KQ62653 | Human | 5349 | Details Get a Quote |
| FXYD3 Knockout HCT 116 Cell Line | EDJ-KQ71120 | Human | 5349 | Details Get a Quote |
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