FUT7 Gene (Fucosyltransferase 7)
Key regulator of selectin ligand synthesis and leukocyte trafficking
Gene Information Card
| Symbol | FUT7 |
|---|---|
| Full Name | Fucosyltransferase 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 2529 ncbi.nlm.nih.gov/gene/2529 |
| Ensembl ID | ENSG00000107175 |
| UniProt ID | Q11130 |
| OMIM ID | 602265 |
| HGNC ID | 4018 |
| Aliases | FucT-VII, Fucosyltransferase 7 |
Description
FUT7 encodes fucosyltransferase 7 (FucT-VII), a Golgi enzyme that catalyzes the transfer of fucose to sialylated lactosamine acceptors, forming sialyl Lewis X (sLe^x) and related selectin ligands. These glycans are essential for leukocyte rolling and homing to inflamed tissues. FUT7 is primarily expressed in leukocytes and is involved in immune surveillance, inflammation, and cancer metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Leukocyte adhesion deficiency type II (LAD II) | Loss of FUT7 function reduces selectin ligand expression, impairing neutrophil adhesion and trafficking. | OMIM #266265; mutations in SLC35C1 (GDP-fucose transporter) cause LAD II with secondary FUT7 deficiency. |
| Rheumatoid arthritis | Upregulated FUT7 in synovial T cells enhances sLe^x expression and joint infiltration. | PubMed studies; increased FUT7 mRNA in RA synovial fluid. |
| Colorectal cancer metastasis | FUT7 overexpression promotes sLe^x synthesis on tumor cells, facilitating E-selectin-mediated metastasis. | COSMIC; multiple studies show correlation with poor prognosis. |
| Acute myeloid leukemia (AML) | Aberrant FUT7 expression contributes to leukocyte adhesion and extramedullary infiltration. | ClinVar; expression data from AML patient samples. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Spleen | 6.7 | Low |
| Whole blood | 4.2 | Low |
| Lung | 1.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (promyeloblast) | 15.2 | High; used as model for neutrophil differentiation |
| Jurkat (T-cell) | 9.8 | Moderate; constitutive expression |
| THP-1 (monocyte) | 7.5 | Low; inducible by TNF-α |
| K562 (erythroleukemia) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; no functional protein |
| c.329G>A (p.Arg110Gln) | missense | <0.01% | Reduced enzyme activity; associated with LAD II-like phenotype |
| c.503C>T (p.Thr168Ile) | missense | <0.01% | Decreased fucosylation; rare population variant |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg110Gln) reduce or abolish fucosyltransferase activity, impairing selectin ligand synthesis and leukocyte adhesion.
Gain of Function (GOF)
Not reported in germline; somatic overexpression in cancers is considered a gain-of-function at the expression level.
Dominant Negative (DN)
No dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
| • Golgi apparatus (GO:0005794) | • integral component of membrane (GO:0016021) |
| • fucosyltransferase activity (GO:0008417) | • protein glycosylation (GO:0006486) |
| • cell adhesion (GO:0007155) | • leukocyte migration (GO:0050900) |
Pathways
• Selectin-mediated leukocyte adhesion (Reactome: R-HSA-202733)
• Fucosylation of glycoproteins (Reactome: R-HSA-975578)
• Sialyl Lewis X biosynthesis (KEGG: hsa00512)
Protein Summary
Fucosyltransferase 7 (FucT-VII) is a 342-amino acid type II transmembrane protein localized to the Golgi. It catalyzes the final step in the synthesis of sialyl Lewis X (sLe^x), a tetrasaccharide ligand for E-, P-, and L-selectins. FucT-VII is critical for leukocyte rolling and extravasation during inflammation. Its expression is tightly regulated in hematopoietic cells and is upregulated in various cancers, promoting metastasis. The protein contains a conserved fucosyltransferase catalytic domain and requires GDP-fucose as a donor substrate.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FUT7 Knockout HEK293 Cell Line | EDJ-KQ50286 | Human | 2529 | Details Get a Quote |
| FUT7 Knockout HeLa Cell Line | EDJ-KQ53280 | Human | 2529 | Details Get a Quote |
| FUT7 Knockout A-549 Cell Line | EDJ-KQ61762 | Human | 2529 | Details Get a Quote |
| FUT7 Knockout HCT 116 Cell Line | EDJ-KQ70244 | Human | 2529 | Details Get a Quote |
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