FSTL5
Follistatin Like 5
Gene Information Card
| Symbol | FSTL5 |
|---|---|
| Full Name | follistatin like 5 |
| Gene Type | protein coding |
| Chromosomal Location | 4q32.2 |
| NCBI Gene ID | 56884 ncbi.nlm.nih.gov/gene/56884 |
| Ensembl ID | ENSG00000138685 |
| UniProt ID | Q8N475 |
| OMIM ID | 617058 |
| HGNC ID | 21386 |
| Aliases | KIAA1263, FLJ33814 |
Description
FSTL5 (follistatin like 5) is a protein-coding gene located on chromosome 4q32.2. It encodes a secreted glycoprotein belonging to the follistatin family, which modulates TGF-beta superfamily signaling. FSTL5 is involved in cell growth regulation and has been implicated in various cancers, including hepatocellular carcinoma and neuroblastoma.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression promotes tumor growth via TGF-beta pathway modulation | PMID: 25944712 |
| Neuroblastoma | Hypermethylation and reduced expression associated with poor prognosis | PMID: 21575862 |
| Colorectal cancer | Upregulation correlates with metastasis and worse survival | PMID: 29228537 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.1 | Low |
| Liver | 3.8 | Low |
| Testis | 2.9 | Low |
| Lung | 1.2 | Not detected |
| Kidney | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 4.5 | Hepatocellular carcinoma cell line |
| SH-SY5Y | 3.2 | Neuroblastoma cell line |
| HEK293 | 1.1 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T | missense | <0.1% | p.Arg349Trp; uncertain significance |
| c.782G>A | missense | <0.1% | p.Arg261His; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function variants reported.
Gain of Function (GOF)
Not established; no confirmed gain-of-function variants reported.
Dominant Negative (DN)
Not established; no evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • heparin binding |
| • signal transduction | • negative regulation of BMP signaling pathway |
Pathways
• TGF-beta signaling pathway
• BMP signaling pathway
Protein Summary
FSTL5 is a secreted glycoprotein of approximately 70 kDa. It contains a follistatin-like domain and an EF-hand calcium-binding domain. The protein modulates TGF-beta superfamily signaling, particularly BMP signaling, by binding to ligands and inhibiting receptor activation. It is implicated in cell proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FSTL5 Knockout HEK293 Cell Line | EDJ-KQ13527 | Human | 56884 | Details Get a Quote |
| FSTL5 Knockout HeLa Cell Line | EDJ-KQ56758 | Human | 56884 | Details Get a Quote |
| FSTL5 Knockout A-549 Cell Line | EDJ-KQ65263 | Human | 56884 | Details Get a Quote |
| FSTL5 Knockout HCT 116 Cell Line | EDJ-KQ73704 | Human | 56884 | Details Get a Quote |
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