FST
Follistatin Gene
Gene Information Card
| Symbol | FST |
|---|---|
| Full Name | Follistatin |
| Gene Type | protein-coding |
| Chromosomal Location | 5q11.2 |
| NCBI Gene ID | 10468 ncbi.nlm.nih.gov/gene/10468 |
| Ensembl ID | ENSG00000134363 |
| UniProt ID | P19883 |
| OMIM ID | 136470 |
| HGNC ID | 3971 |
| Aliases | FS, activin-binding protein |
Description
The FST gene encodes follistatin, a secreted glycoprotein that binds to and neutralizes activin, a member of the TGF-beta superfamily. Follistatin regulates cell proliferation, differentiation, and apoptosis, and plays critical roles in development, reproduction, and muscle growth.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Polycystic Ovary Syndrome (PCOS) | Altered follistatin levels disrupt activin signaling, contributing to ovarian dysfunction | PMID: 21802014 |
| Premature Ovarian Failure | FST mutations may impair activin regulation, affecting folliculogenesis | PMID: 19502567 |
| Cancer (various) | Follistatin overexpression can promote tumor growth by inhibiting activin's tumor-suppressive effects | PMID: 23382250 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Ovary | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Adrenal Gland | 6.7 | Low |
| Cerebral Cortex | 4.2 | Low |
| Skeletal Muscle | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| K562 | 7.8 | Chronic myelogenous leukemia cell line |
| A549 | 5.4 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.431C>T (p.Pro144Leu) | Missense | <0.01% | Unknown; reported in ClinVar |
| c.589G>A (p.Gly197Arg) | Missense | <0.01% | Unknown; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • activin binding | • heparin binding |
| • extracellular space | • negative regulation of cell proliferation |
| • negative regulation of activin receptor signaling pathway |
Pathways
• TGF-beta signaling pathway
• Activin receptor signaling pathway
Protein Summary
Follistatin is a 344-amino-acid secreted glycoprotein that binds activin with high affinity, blocking its interaction with receptors. It contains multiple follistatin-like domains and is involved in regulating cell growth, differentiation, and apoptosis. The protein is expressed in various tissues, with highest levels in ovary and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FST Knockout HEK293 Cell Line | EDJ-KQ379 | Human | 10468 | Details Get a Quote |
| FSTL1 Knockout HEK293 Cell Line | EDJ-KQ3736 | Human | 11167 | Details Get a Quote |
| FSTL3 Knockout HEK293 Cell Line | EDJ-KQ6985 | Human | 10272 | Details Get a Quote |
| FSTL4 Knockout HEK293 Cell Line | EDJ-KQ7830 | Human | 23105 | Details Get a Quote |
| FSTL5 Knockout HEK293 Cell Line | EDJ-KQ13527 | Human | 56884 | Details Get a Quote |
| FSTL4 Knockout HeLa Cell Line | EDJ-KQ32043 | Human | 23105 | Details Get a Quote |
| FST Knockout A-549 Cell Line | EDJ-KQ18584 | Human | 10468 | Details Get a Quote |
| FST Knockout HeLa Cell Line | EDJ-KQ18585 | Human | 10468 | Details Get a Quote |
| FSTL1 Knockout HeLa Cell Line | EDJ-KQ24424 | Human | 11167 | Details Get a Quote |
| FSTL1 Knockout A-549 Cell Line | EDJ-KQ25787 | Human | 11167 | Details Get a Quote |
| FSTL1 Knockout HCT 116 Cell Line | EDJ-KQ25788 | Human | 11167 | Details Get a Quote |
| FSTL3 Knockout A-549 Cell Line | EDJ-KQ30312 | Human | 10272 | Details Get a Quote |
| FSTL3 Knockout HCT 116 Cell Line | EDJ-KQ31695 | Human | 10272 | Details Get a Quote |
| FSTL3 Knockout HeLa Cell Line | EDJ-KQ31696 | Human | 10272 | Details Get a Quote |
| FSTL5 Knockout HeLa Cell Line | EDJ-KQ56758 | Human | 56884 | Details Get a Quote |
Displaying Records 1 To 15 Of 20 Records
