FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit)
A member of the FOS family of transcription factors, involved in cell proliferation, differentiation, and transformation.
Gene Information Card
| Symbol | FOSL2 |
|---|---|
| Full Name | FOS Like 2, AP-1 Transcription Factor Subunit |
| Gene Type | Protein coding |
| Chromosomal Location | 2p23.2 |
| NCBI Gene ID | 2355 ncbi.nlm.nih.gov/gene/2355 |
| Ensembl ID | ENSG00000175426 |
| UniProt ID | P15408 |
| OMIM ID | 601575 |
| HGNC ID | 4018 |
| Aliases | FRA-2, FOSL2, AP-1 |
Description
FOSL2 (FOS Like 2) encodes a leucine zipper protein that dimerizes with JUN proteins to form the transcription factor complex AP-1. This complex regulates gene expression in response to a variety of stimuli, including growth factors, cytokines, and stress signals. FOSL2 is involved in cell proliferation, differentiation, and transformation, and its dysregulation is implicated in several cancers and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of FOSL2 promotes cell proliferation and invasion via AP-1 target genes | PMID: 23454763 |
| Lung cancer | FOSL2 amplification and overexpression contribute to tumor progression | PMID: 25652252 |
| Rheumatoid arthritis | FOSL2 upregulation in synovial fibroblasts drives inflammation and joint destruction | PMID: 21411739 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Bone marrow | 3.1 | Low |
| Skin | 15.2 | Medium |
| Lymph node | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 18.4 | High expression |
| MCF7 (breast cancer) | 9.2 | Moderate expression |
| HEK293 (embryonic kidney) | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.500G>A (p.Arg167Gln) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.742C>T (p.Arg248Trp) | Missense | <0.1% in COSMIC | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Amplification and overexpression observed in cancers, suggesting potential gain-of-function role.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • RNA polymerase II core promoter sequence-specific binding (GO:0000982) | • DNA-binding transcription factor activity (GO:0003700) |
| • regulation of transcription by RNA polymerase II (GO:0006357) | • cell proliferation (GO:0008283) |
| • cell differentiation (GO:0030154) |
Pathways
• AP-1 transcription factor network
• TNF signaling pathway
• IL-17 signaling pathway
• MAPK signaling pathway
Protein Summary
FOSL2 (FRA-2) is a 326-amino acid protein containing a basic leucine zipper (bZIP) domain. It heterodimerizes with JUN proteins to form the AP-1 complex, which binds to TRE (TPA response element) sequences in DNA. FOSL2 is involved in regulating cell cycle, apoptosis, and differentiation. Its expression is induced by growth factors and stress signals, and it plays a role in bone development, immune response, and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FOSL2 Knockout HEK293 Cell Line | EDJ-KQ1694 | Human | 2355 | Details Get a Quote |
| FOSL2 Knockout A-549 Cell Line | EDJ-KQ22822 | Human | 2355 | Details Get a Quote |
| FOSL2 Knockout HCT 116 Cell Line | EDJ-KQ22824 | Human | 2355 | Details Get a Quote |
| FOSL2 Knockout HeLa Cell Line | EDJ-KQ22825 | Human | 2355 | Details Get a Quote |
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