FOSB: FBJ Murine Osteosarcoma Viral Oncogene Homolog B
A member of the AP-1 transcription factor family involved in cell proliferation, differentiation, and transformation.
Gene Information Card
| Symbol | FOSB |
|---|---|
| Full Name | FBJ murine osteosarcoma viral oncogene homolog B |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 2354 ncbi.nlm.nih.gov/gene/2354 |
| Ensembl ID | ENSG00000125740 |
| UniProt ID | P53539 |
| OMIM ID | 164772 |
| HGNC ID | 3797 |
| Aliases | G0S3, GOS3, GOSB, AP-1 |
Description
FOSB encodes a leucine zipper protein that dimerizes with JUN proteins to form the AP-1 transcription factor complex. It regulates gene expression in response to extracellular signals, influencing cell proliferation, differentiation, and apoptosis. FOSB is implicated in osteosarcoma and other cancers, and its expression is induced by growth factors and stress stimuli.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteosarcoma | FOSB overexpression due to chromosomal rearrangements (e.g., FOSB-COL1A1 fusion) drives tumorigenesis via AP-1 activation. | PMID: 25944712; COSMIC |
| Epithelioid hemangioma | Recurrent FOSB fusions (e.g., SERPINE1-FOSB) lead to constitutive AP-1 signaling. | PMID: 31061136; ClinVar |
| Pseudomyogenic hemangioendothelioma | FOSB rearrangements (e.g., ACTB-FOSB) result in oncogenic fusion proteins. | PMID: 31061136; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone | 2.3 | Low |
| Brain | 1.8 | Low |
| Heart | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
| Lung | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 3.5 | Moderate expression |
| A549 | 2.1 | Low expression |
| MCF7 | 1.0 | Not detected |
| U2OS | 4.8 | High expression (osteosarcoma cell line) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| FOSB-COL1A1 fusion | Gene fusion | Rare in osteosarcoma | Oncogenic activation of AP-1 |
| SERPINE1-FOSB fusion | Gene fusion | Recurrent in epithelioid hemangioma | Constitutive AP-1 signaling |
| ACTB-FOSB fusion | Gene fusion | Recurrent in pseudomyogenic hemangioendothelioma | Oncogenic fusion protein |
Mutation functional classification
Loss of Function (LOF)
Not reported for FOSB; loss-of-function mutations are not characteristic.
Gain of Function (GOF)
FOSB fusions (e.g., COL1A1-FOSB, SERPINE1-FOSB) result in gain-of-function via constitutive AP-1 activity.
Dominant Negative (DN)
Not described for FOSB.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (hsa04010)
• Osteoclast differentiation (hsa04380)
• IL-17 signaling pathway (hsa04657)
• TNF signaling pathway (hsa04668)
Protein Summary
FOSB is a 338-amino acid protein (UniProt P53539) containing a basic leucine zipper (bZIP) domain. It heterodimerizes with JUN proteins to form the AP-1 transcription factor complex, which binds to TRE/AP-1 elements in target gene promoters. FOSB is rapidly induced by growth factors and stress signals, and its expression is tightly regulated. Aberrant FOSB fusions drive oncogenesis in mesenchymal tumors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FOSB Knockout HEK293 Cell Line | EDJ-KQ4621 | Human | 2354 | Details Get a Quote |
| FOSB Knockout A-549 Cell Line | EDJ-KQ27291 | Human | 2354 | Details Get a Quote |
| FOSB Knockout HCT 116 Cell Line | EDJ-KQ27292 | Human | 2354 | Details Get a Quote |
| FOSB Knockout HeLa Cell Line | EDJ-KQ53262 | Human | 2354 | Details Get a Quote |
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