FOLR3
Folate Receptor 3 (Gamma)
Gene Information Card
| Symbol | FOLR3 |
|---|---|
| Full Name | Folate Receptor 3 (Gamma) |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.4 |
| NCBI Gene ID | 2352 ncbi.nlm.nih.gov/gene/2352 |
| Ensembl ID | ENSG00000165376 |
| UniProt ID | P41439 |
| OMIM ID | 602469 |
| HGNC ID | 3794 |
| Aliases | FR-gamma, FR-G, FOLR1P, FOLR2P |
Description
FOLR3 encodes folate receptor gamma (FR-gamma), a member of the folate receptor family that binds and transports folate (vitamin B9). Unlike other family members, FR-gamma is a secreted protein lacking a glycosylphosphatidylinositol (GPI) anchor. It is primarily expressed in placenta, kidney, and certain hematopoietic cells, and may play a role in folate homeostasis and immune modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Folate deficiency | Reduced folate binding capacity due to altered FOLR3 expression | PMID: 10861294 |
| Neural tube defects | Potential contribution via impaired folate transport | PMID: 14586451 |
| Cancer (ovarian, breast) | Aberrant FOLR3 expression may affect folate availability for tumor growth | PMID: 12629541 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Lung | 1.2 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| JEG-3 (placental) | 15.2 | Moderate expression |
| MCF7 (breast) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.458C>T (p.Thr153Ile) | missense | <0.01% | May affect protein stability |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • folate binding | • folic acid transport |
| • receptor-mediated endocytosis | • cell surface |
| • extracellular region |
Pathways
• Folate transport
• One-carbon metabolism
Protein Summary
Folate receptor gamma is a 243-amino-acid secreted protein that binds folic acid and reduced folates with high affinity. Unlike GPI-anchored family members (FOLR1, FOLR2), FR-gamma lacks a membrane anchor and is released extracellularly. It is expressed in placenta and kidney, and may modulate folate availability in these tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FOLR3 Knockout HEK293 Cell Line | EDJ-KQ3857 | Human | 2352 | Details Get a Quote |
| FOLR3 Knockout HeLa Cell Line | EDJ-KQ53261 | Human | 2352 | Details Get a Quote |
| FOLR3 Knockout A-549 Cell Line | EDJ-KQ61745 | Human | 2352 | Details Get a Quote |
| FOLR3 Knockout HCT 116 Cell Line | EDJ-KQ70230 | Human | 2352 | Details Get a Quote |
