FLT3LG
FMS-related tyrosine kinase 3 ligand
Gene Information Card
| Symbol | FLT3LG |
|---|---|
| Full Name | fms-related tyrosine kinase 3 ligand |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 2323 ncbi.nlm.nih.gov/gene/2323 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | P49771 |
| OMIM ID | 136431 |
| HGNC ID | 3766 |
| Aliases | FLT3L, FL, FLT3 ligand |
Description
FLT3LG encodes the ligand for the FLT3 receptor tyrosine kinase, a cytokine critical for hematopoiesis, particularly the development of dendritic cells, natural killer cells, and hematopoietic stem cell maintenance. It is expressed in various tissues and promotes cell survival, proliferation, and differentiation upon binding to FLT3.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | FLT3LG overexpression may contribute to leukemogenesis by activating FLT3 signaling | PMID: 12091329 |
| Myelodysplastic syndromes | Altered FLT3LG levels may affect hematopoietic stem cell niche | PMID: 16990592 |
| Graft-versus-host disease | FLT3LG administration can modulate dendritic cell activity | PMID: 15536153 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 0.8 | Low |
| Spleen | 1.2 | Low |
| Lung | 0.5 | Not detected |
| Thymus | 1.0 | Low |
| Peripheral blood mononuclear cells | 2.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.3 | Low expression |
| K562 | 0.6 | Low expression |
| THP-1 | 1.8 | Medium expression |
| Jurkat | 0.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | Rare | Unknown functional effect |
| c.200C>T | missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in FLT3LG.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in FLT3LG.
Dominant Negative (DN)
No dominant-negative mutations reported in FLT3LG.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity | • growth factor activity |
| • extracellular space | • positive regulation of cell proliferation |
| • positive regulation of protein tyrosine kinase activity |
Pathways
• FLT3 signaling pathway
• Cytokine-cytokine receptor interaction
• Hematopoietic cell lineage
Protein Summary
FLT3LG is a transmembrane protein that can be cleaved to produce a soluble form. It binds to the FLT3 receptor on hematopoietic progenitor cells, activating downstream signaling pathways such as PI3K/AKT and MAPK, promoting cell survival, proliferation, and differentiation. It is essential for dendritic cell development and maintenance of hematopoietic stem cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FLT3LG Knockout HEK293 Cell Line | EDJ-KQ1200 | Human | 2323 | Details Get a Quote |
| FLT3LG Knockout A-549 Cell Line | EDJ-KQ20507 | Human | 2323 | Details Get a Quote |
| FLT3LG Knockout HCT 116 Cell Line | EDJ-KQ20508 | Human | 2323 | Details Get a Quote |
| FLT3LG Knockout HeLa Cell Line | EDJ-KQ20509 | Human | 2323 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
