FLOT2 Gene - Flotillin 2
A key regulator of membrane microdomains and signal transduction
Gene Information Card
| Symbol | FLOT2 |
|---|---|
| Full Name | Flotillin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 2319 ncbi.nlm.nih.gov/gene/2319 |
| Ensembl ID | ENSG00000108578 |
| UniProt ID | Q14254 |
| OMIM ID | 606998 |
| HGNC ID | 3758 |
| Aliases | ESA, M17S1, flotillin-2 |
Description
FLOT2 encodes flotillin 2, a membrane-associated protein that localizes to lipid rafts and caveolae. It is involved in vesicle trafficking, cell adhesion, and signal transduction. FLOT2 is upregulated in several cancers and may promote tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | FLOT2 overexpression promotes cell proliferation and migration via PI3K/Akt pathway | PMID: 25605247 |
| Gastric cancer | FLOT2 upregulation correlates with poor prognosis and metastasis | PMID: 24860983 |
| Hepatocellular carcinoma | FLOT2 enhances invasion through EMT induction | PMID: 27058631 |
| Colorectal cancer | FLOT2 expression associated with lymph node metastasis | PMID: 26159173 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 23.5 | High |
| Heart | 18.2 | Medium |
| Liver | 12.1 | Medium |
| Lung | 15.8 | Medium |
| Kidney | 20.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.1 | Cervical cancer cell line |
| MCF7 | 19.4 | Breast cancer cell line |
| A549 | 17.6 | Lung cancer cell line |
| HepG2 | 14.3 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.500C>T (p.Pro167Leu) | Missense | 0.02% | Unknown functional impact |
| c.763G>A (p.Glu255Lys) | Missense | 0.01% | Reported in COSMIC |
| c.1120_1121insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein are likely loss-of-function.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function role, but specific activating mutations are not well characterized.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • membrane raft | • caveola |
| • protein binding | • signal transduction |
| • vesicle-mediated transport |
Pathways
• PI3K-Akt signaling pathway
• Ras signaling
• Integrin signaling
Protein Summary
Flotillin 2 is a 428-amino acid protein that forms hetero-oligomeric complexes with flotillin 1. It is anchored to the plasma membrane via myristoylation and palmitoylation, and participates in endocytosis, cell adhesion, and receptor signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FLOT2 Knockout HEK293 Cell Line | EDJ-KQ4612 | Human | 2319 | Details Get a Quote |
| FLOT2 Knockout HeLa Cell Line | EDJ-KQ26042 | Human | 2319 | Details Get a Quote |
| FLOT2 Knockout A-549 Cell Line | EDJ-KQ27286 | Human | 2319 | Details Get a Quote |
| FLOT2 Knockout HCT 116 Cell Line | EDJ-KQ27287 | Human | 2319 | Details Get a Quote |
