FLOT1 Gene - Flotillin 1
Comprehensive genomic and proteomic analysis of FLOT1, a lipid raft marker involved in membrane trafficking and signal transduction.
Gene Information Card
| Symbol | FLOT1 |
|---|---|
| Full Name | flotillin 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.33 |
| NCBI Gene ID | 10211 ncbi.nlm.nih.gov/gene/10211 |
| Ensembl ID | ENSG00000137312 |
| UniProt ID | O75955 |
| OMIM ID | 606998 |
| HGNC ID | 3757 |
| Aliases | FLOT1, flotillin-1, M17S2 |
Description
FLOT1 (flotillin 1) encodes a membrane-associated protein that localizes to lipid rafts and caveolae. It functions in vesicle trafficking, cell adhesion, and signal transduction. FLOT1 is widely expressed and has been implicated in cancer progression, neurodegenerative diseases, and viral entry.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | FLOT1 overexpression promotes cell proliferation and migration via PI3K/Akt pathway | PMID: 25642768 |
| Alzheimer disease | FLOT1 interacts with amyloid precursor protein and modulates Aβ production | PMID: 22171009 |
| Hepatocellular carcinoma | FLOT1 upregulation correlates with poor prognosis and metastasis | PMID: 28407145 |
| Prostate cancer | FLOT1 knockdown reduces tumor growth and invasion in vitro | PMID: 27323851 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 18.5 | Medium |
| Lung | 12.3 | Medium |
| Liver | 8.7 | Low |
| Kidney | 15.1 | Medium |
| Heart | 10.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 22.4 | High expression |
| HeLa | 19.8 | High expression |
| MCF7 | 16.2 | Medium expression |
| A549 | 14.5 | Medium expression |
| HepG2 | 11.3 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | 0.02% (gnomAD) | Unknown functional impact |
| c.682G>A (p.Glu228Lys) | Missense | 0.01% (gnomAD) | Predicted benign |
| c.1003C>T (p.Arg335Trp) | Missense | 0.005% (gnomAD) | Predicted damaging (SIFT) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in FLOT1.
Gain of Function (GOF)
Overexpression in multiple cancers suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • caveola (GO:0005901) |
| • endocytosis (GO:0006897) | • signal transduction (GO:0007165) |
| • membrane (GO:0016020) | • cytoplasmic vesicle (GO:0031410) |
Pathways
• Raft-dependent endocytosis (Reactome: R-HSA-5620912)
• Signal transduction by flotillins (Reactome: R-HSA-5620916)
Protein Summary
Flotillin 1 is a 427-amino acid protein (47 kDa) that associates with lipid rafts via palmitoylation and myristoylation. It forms hetero-oligomers with flotillin 2 and participates in membrane microdomain organization, endocytosis, and cell signaling. The protein contains a prohibitin homology (PHB) domain and a flotillin domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FLOT1 Knockout HEK293 Cell Line | EDJ-KQ3396 | Human | 10211 | Details Get a Quote |
| FLOT1 Knockout A-549 Cell Line | EDJ-KQ25090 | Human | 10211 | Details Get a Quote |
| FLOT1 Knockout HCT 116 Cell Line | EDJ-KQ25091 | Human | 10211 | Details Get a Quote |
| FLOT1 Knockout HeLa Cell Line | EDJ-KQ23704 | Human | 10211 | Details Get a Quote |
