FGR (FGR Proto-Oncogene, Src Family Tyrosine Kinase)
A member of the Src family of non-receptor tyrosine kinases involved in cell growth, differentiation, and immune signaling.
Gene Information Card
| Symbol | FGR |
|---|---|
| Full Name | FGR proto-oncogene, Src family tyrosine kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 1p35.3 |
| NCBI Gene ID | 2268 ncbi.nlm.nih.gov/gene/2268 |
| Ensembl ID | ENSG00000100902 |
| UniProt ID | P09769 |
| OMIM ID | 164940 |
| HGNC ID | 3625 |
| Aliases | c-fgr, p55c-fgr, SRC2 |
Description
FGR is a proto-oncogene encoding a member of the Src family of non-receptor tyrosine kinases. The protein is involved in signal transduction pathways regulating cell proliferation, differentiation, adhesion, and migration. It is primarily expressed in hematopoietic cells, particularly monocytes and macrophages, and plays a role in immune response. Aberrant expression or mutations have been implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Myeloid Leukemia | FGR overexpression may contribute to leukemogenesis via enhanced kinase activity and downstream signaling | PMID: 10523307 |
| Breast Cancer | FGR amplification and overexpression associated with poor prognosis and increased cell migration | PMID: 24651015 |
| Colorectal Cancer | FGR upregulation promotes tumor growth and metastasis through Src-family kinase pathways | PMID: 25485619 |
| Systemic Lupus Erythematosus | FGR polymorphisms linked to altered immune cell signaling and autoimmunity | PMID: 20062063 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 4.1 | Low |
| Whole Blood | 3.9 | Low |
| Lymph Node | 6.7 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocytic leukemia) | 15.2 | High expression |
| K-562 (CML) | 10.8 | Moderate expression |
| MCF7 (breast cancer) | 2.1 | Low expression |
| HCT116 (colorectal cancer) | 4.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1084C>T (p.Arg362Trp) | Missense | <0.01% | Unknown; predicted damaging |
| c.1435G>A (p.Gly479Arg) | Missense | <0.01% | Unknown; predicted benign |
| c.1666C>T (p.Arg556Cys) | Missense | <0.01% | Unknown; predicted damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
Amplification and overexpression observed in several cancers, suggesting gain-of-function role.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• KEGG: hsa04020 – Calcium signaling pathway
• KEGG: hsa04660 – T cell receptor signaling pathway
• KEGG: hsa04810 – Regulation of actin cytoskeleton
• Reactome: R-HSA-177929 – Signaling by SCF-KIT
• Reactome: R-HSA-2029480 – Fcgamma receptor (FCGR) dependent phagocytosis
Protein Summary
The FGR protein (UniProt P09769) is a 529-amino acid non-receptor tyrosine kinase with SH3, SH2, and tyrosine kinase domains. It localizes to the plasma membrane and cytoplasm, and is activated by various extracellular signals. FGR phosphorylates downstream targets involved in cytoskeletal rearrangement, cell adhesion, and immune receptor signaling. Its kinase activity is regulated by phosphorylation at Tyr-412 (activating) and Tyr-523 (inhibitory).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGR Knockout HEK293 Cell Line | EDJ-KQ4593 | Human | 2268 | Details Get a Quote |
| FGR Knockout HeLa Cell Line | EDJ-KQ53234 | Human | 2268 | Details Get a Quote |
| FGR Knockout A-549 Cell Line | EDJ-KQ61713 | Human | 2268 | Details Get a Quote |
| FGR Knockout HCT 116 Cell Line | EDJ-KQ70199 | Human | 2268 | Details Get a Quote |
