FGFBP3
Fibroblast Growth Factor Binding Protein 3
Gene Information Card
| Symbol | FGFBP3 |
|---|---|
| Full Name | fibroblast growth factor binding protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q23.32 |
| NCBI Gene ID | 143282 ncbi.nlm.nih.gov/gene/143282 |
| Ensembl ID | ENSG00000138193 |
| UniProt ID | Q8TAT2 |
| OMIM ID | 617273 |
| HGNC ID | 23368 |
| Aliases | FGF-BP3, FGFBP-3, FGFBP3a, FGFBP3b |
Description
FGFBP3 (fibroblast growth factor binding protein 3) encodes a secreted protein that binds fibroblast growth factors (FGFs) and modulates their bioavailability and signaling. It is involved in cell growth, differentiation, and angiogenesis. The gene is located on chromosome 10q23.32 and is expressed in various tissues, with notable roles in cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of FGFBP3 may enhance FGF signaling, promoting tumor growth and angiogenesis. | PMID: 23469117 |
| Colorectal cancer | FGFBP3 upregulation correlates with poor prognosis and may contribute to FGF-driven proliferation. | PMID: 25695676 |
| Prostate cancer | FGFBP3 expression is elevated in metastatic lesions, potentially facilitating FGF-mediated invasion. | PMID: 27050027 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 5.2 | Low |
| Brain | 1.8 | Not detected |
| Breast | 12.4 | Medium |
| Colon | 8.9 | Low |
| Heart | 2.1 | Not detected |
| Kidney | 6.3 | Low |
| Liver | 3.5 | Not detected |
| Lung | 7.1 | Low |
| Prostate | 15.6 | Medium |
| Skin | 9.8 | Low |
| Testis | 4.4 | Not detected |
| Thyroid | 11.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 22.3 | High expression |
| HCT116 (colorectal cancer) | 18.7 | High expression |
| PC3 (prostate cancer) | 14.5 | Medium expression |
| A549 (lung cancer) | 9.1 | Low expression |
| HEK293 (embryonic kidney) | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T (p.Pro79Leu) | missense | 0.02% (gnomAD) | Unknown functional impact |
| c.487G>A (p.Gly163Arg) | missense | 0.01% (gnomAD) | Predicted benign |
| c.602_603insA (p.Asn201Lysfs*12) | frameshift | Rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.602_603insA) are predicted to cause premature truncation and loss of FGF-binding activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in FGFBP3.
Dominant Negative (DN)
No evidence of dominant-negative effects for FGFBP3 mutations.
View complete mutation data：
Gene Ontology (GO)
| • fibroblast growth factor binding (GO:0017137) | • extracellular region (GO:0005576) |
| • extracellular space (GO:0005615) | • growth factor activity (GO:0008083) |
| • receptor ligand activity (GO:0048018) |
Pathways
• FGF signaling pathway (Reactome: R-HSA-190236)
• Signaling by FGFR (Reactome: R-HSA-190237)
• Angiogenesis (KEGG: hsa04370)
Protein Summary
FGFBP3 is a secreted protein of approximately 27 kDa that binds fibroblast growth factors (FGFs) with high affinity, modulating their release from the extracellular matrix and enhancing FGF receptor signaling. It is implicated in developmental processes and tumor progression, particularly in breast, colorectal, and prostate cancers. The protein contains a signal peptide and a conserved FGF-binding domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGFBP3 Knockout HEK293 Cell Line | EDJ-KQ10341 | Human | 143282 | Details Get a Quote |
| FGFBP3 Knockout A-549 Cell Line | EDJ-KQ37640 | Human | 143282 | Details Get a Quote |
| FGFBP3 Knockout HCT 116 Cell Line | EDJ-KQ37641 | Human | 143282 | Details Get a Quote |
| FGFBP3 Knockout HeLa Cell Line | EDJ-KQ37642 | Human | 143282 | Details Get a Quote |
