FGFBP2
Fibroblast Growth Factor Binding Protein 2
Gene Information Card
| Symbol | FGFBP2 |
|---|---|
| Full Name | Fibroblast Growth Factor Binding Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p15.32 |
| NCBI Gene ID | 100289361 ncbi.nlm.nih.gov/gene/100289361 |
| Ensembl ID | ENSG00000214575 |
| UniProt ID | Q9BYJ0 |
| OMIM ID | 617273 |
| HGNC ID | 33827 |
| Aliases | FGF-BP2, FGFBP-2, HBP17 |
Description
FGFBP2 encodes a secreted protein that binds fibroblast growth factors (FGFs) and modulates their bioavailability and activity. It is involved in cell proliferation, differentiation, and angiogenesis. Expression is often altered in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of FGFBP2 enhances FGF signaling, promoting tumor growth and angiogenesis | PMID: 23454753 |
| Colorectal cancer | Upregulation correlates with poor prognosis and increased metastatic potential | PMID: 25645678 |
| Gastric cancer | FGFBP2 amplification drives FGF-dependent proliferation | PMID: 27889123 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 0.8 | Low |
| Liver | 0.5 | Low |
| Lung | 1.2 | Low |
| Breast | 3.5 | Medium |
| Colon | 2.1 | Medium |
| Stomach | 4.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 5.2 | Moderate expression |
| HCT116 (colorectal cancer) | 3.8 | Moderate expression |
| AGS (gastric cancer) | 6.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Amplification or overexpression observed in cancers, suggesting potential gain-of-function.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • fibroblast growth factor binding (GO:0017134) | • extracellular region (GO:0005576) |
| • cell proliferation (GO:0008283) |
Pathways
• FGF signaling pathway (Reactome: R-HSA-190236)
• Angiogenesis (KEGG: hsa04370)
Protein Summary
FGFBP2 is a 234-amino acid secreted protein that binds FGFs (especially FGF1 and FGF2) and enhances their interaction with FGF receptors. It plays a role in tissue repair, angiogenesis, and tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGFBP2 Knockout HEK293 Cell Line | EDJ-KQ3082 | Human | 83888 | Details Get a Quote |
| FGFBP2 Knockout HeLa Cell Line | EDJ-KQ57497 | Human | 83888 | Details Get a Quote |
| FGFBP2 Knockout A-549 Cell Line | EDJ-KQ66000 | Human | 83888 | Details Get a Quote |
| FGFBP2 Knockout HCT 116 Cell Line | EDJ-KQ74423 | Human | 83888 | Details Get a Quote |
