FGFBP1 (Fibroblast Growth Factor Binding Protein 1)
A secreted protein that modulates FGF signaling and is implicated in cancer progression and wound healing.
Gene Information Card
| Symbol | FGFBP1 |
|---|---|
| Full Name | Fibroblast Growth Factor Binding Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p15.32 |
| NCBI Gene ID | 9982 ncbi.nlm.nih.gov/gene/9982 |
| Ensembl ID | ENSG00000137440 |
| UniProt ID | Q14512 |
| OMIM ID | 607168 |
| HGNC ID | 3678 |
| Aliases | FGFBP, HBP17 |
Description
FGFBP1 encodes a secreted protein that binds fibroblast growth factors (FGFs) and modulates their bioavailability and activity. It is involved in cell proliferation, differentiation, and angiogenesis. Overexpression is observed in several cancers and is associated with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of FGFBP1 enhances FGF signaling, promoting tumor growth and metastasis. | PMID: 14559847 |
| Colorectal cancer | Elevated FGFBP1 levels correlate with advanced stage and poor survival. | PMID: 19029981 |
| Pancreatic cancer | FGFBP1 upregulation contributes to desmoplasia and chemoresistance. | PMID: 23327982 |
| Wound healing | FGFBP1 is induced during tissue repair and modulates FGF-mediated keratinocyte migration. | PMID: 10811620 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Esophagus | 8.3 | Low |
| Breast | 6.1 | Low |
| Lung | 4.7 | Low |
| Colon | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal cancer) | 9.8 | Moderate expression |
| A549 (lung cancer) | 5.4 | Low expression |
| HaCaT (keratinocyte) | 18.7 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.325C>T (p.Arg109Trp) | Missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• FGF signaling pathway (Reactome: R-HSA-190236)
• Signaling by FGFR (Reactome: R-HSA-190237)
Protein Summary
FGFBP1 is a 234-amino-acid secreted protein that binds FGF-1, FGF-2, and other FGF family members. It protects FGFs from proteolytic degradation and enhances their interaction with FGF receptors, thereby potentiating FGF signaling. The protein is expressed in skin, esophagus, and certain epithelial tissues, and is upregulated in various cancers where it promotes tumor angiogenesis and progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGFBP1 Knockout HEK293 Cell Line | EDJ-KQ6205 | Human | 9982 | Details Get a Quote |
| FGFBP1 Knockout A-549 Cell Line | EDJ-KQ31408 | Human | 9982 | Details Get a Quote |
| FGFBP1 Knockout HCT 116 Cell Line | EDJ-KQ31409 | Human | 9982 | Details Get a Quote |
| FGFBP1 Knockout HeLa Cell Line | EDJ-KQ31410 | Human | 9982 | Details Get a Quote |
