FGF11: Fibroblast Growth Factor 11
A member of the fibroblast growth factor family involved in cellular signaling and development.
Gene Information Card
| Symbol | FGF11 |
|---|---|
| Full Name | Fibroblast Growth Factor 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 2256 ncbi.nlm.nih.gov/gene/2256 |
| Ensembl ID | ENSG00000164631 |
| UniProt ID | Q92914 |
| OMIM ID | 601521 |
| HGNC ID | 3670 |
| Aliases | FHF3, FGF-11 |
Description
FGF11 (Fibroblast Growth Factor 11) is a member of the fibroblast growth factor (FGF) family. Unlike most FGFs, FGF11 lacks a signal peptide and is not secreted; it functions intracellularly and is involved in neuronal development and cell signaling. The gene is located on chromosome 17p13.1 and encodes a protein of 225 amino acids.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.5 | Medium |
| Heart | 3.2 | Low |
| Skeletal Muscle | 2.1 | Low |
| Kidney | 1.8 | Low |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 12.3 | Neuronal model |
| HeLa (cervical carcinoma) | 4.7 | Epithelial |
| HEK293 (embryonic kidney) | 3.1 | Transformed |
| K562 (leukemia) | 1.2 | Myeloid |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations in COSMIC or ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • growth factor activity (GO:0008083) | • protein binding (GO:0005515) |
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
| • multicellular organism development (GO:0007275) |
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5673001)
• FGF signaling (KEGG: hsa04010)
Protein Summary
FGF11 is a 225-amino acid intracellular protein belonging to the FGF family. It lacks a signal peptide and is not secreted, functioning primarily in the cytoplasm and nucleus. It is involved in neuronal development and may modulate MAPK signaling. The protein is encoded by the FGF11 gene on chromosome 17p13.1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGF11 Knockout HEK293 Cell Line | EDJ-KQ2712 | Human | 2256 | Details Get a Quote |
| FGF11 Knockout HCT 116 Cell Line | EDJ-KQ23557 | Human | 2256 | Details Get a Quote |
| FGF11 Knockout HeLa Cell Line | EDJ-KQ23558 | Human | 2256 | Details Get a Quote |
| FGF11 Knockout A-549 Cell Line | EDJ-KQ61707 | Human | 2256 | Details Get a Quote |
