FER
FER Tyrosine Kinase
Gene Information Card
| Symbol | FER |
|---|---|
| Full Name | FER tyrosine kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 5q21.3 |
| NCBI Gene ID | 2241 ncbi.nlm.nih.gov/gene/2241 |
| Ensembl ID | ENSG00000151414 |
| UniProt ID | P16591 |
| OMIM ID | 136830 |
| HGNC ID | 3655 |
| Aliases | TYK3, c-FER, FER (fps/fes related) tyrosine kinase |
Description
The FER gene encodes a member of the FPS/FES family of non-receptor tyrosine kinases. This protein is involved in the regulation of cell-cell adhesion, cell migration, and signal transduction pathways, including those mediated by growth factors and cytokines. FER is implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | FER overexpression promotes cell migration and invasion via STAT3 signaling | PMID: 23431177 |
| Colorectal cancer | FER amplification and activation correlate with poor prognosis and metastasis | PMID: 25944712 |
| Prostate cancer | FER kinase activity enhances androgen receptor signaling and tumor growth | PMID: 27325648 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Lung | 6.3 | Low |
| Breast | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.3 | Leukemia cell line |
| MCF7 | 8.7 | Breast cancer cell line |
| HeLa | 7.2 | Cervical cancer cell line |
| A549 | 6.5 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Gln575His | Missense | <0.1% | Unknown |
| p.Arg678Trp | Missense | <0.1% | Unknown |
| p.Thr706Met | Missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression and amplification of FER are associated with oncogenic signaling in several cancers.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Rap1 signaling pathway (KEGG: hsa04015)
• Focal adhesion (KEGG: hsa04510)
• EGFR tyrosine kinase inhibitor resistance (KEGG: hsa01521)
Protein Summary
FER is a 822-amino acid non-receptor tyrosine kinase containing an N-terminal FCH domain, a central SH2 domain, and a C-terminal tyrosine kinase domain. It localizes to the cytoplasm and plasma membrane, where it phosphorylates substrates involved in cell adhesion, migration, and survival. FER is widely expressed in hematopoietic and epithelial tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FERMT3 Knockout HEK293 Cell Line | EDJ-KQ3108 | Human | 83706 | Details Get a Quote |
| FER Knockout HEK293 Cell Line | EDJ-KQ4594 | Human | 2241 | Details Get a Quote |
| FERMT2 Knockout HEK293 Cell Line | EDJ-KQ7232 | Human | 10979 | Details Get a Quote |
| FERD3L Knockout HEK293 Cell Line | EDJ-KQ9088 | Human | 222894 | Details Get a Quote |
| FER1L5 Knockout HEK293 Cell Line | EDJ-KQ10589 | Human | 90342 | Details Get a Quote |
| FERRY3 Knockout HEK293 Cell Line | EDJ-KQ11938 | Human | 57102 | Details Get a Quote |
| FER1L6 Knockout HEK293 Cell Line | EDJ-KQ13471 | Human | 654463 | Details Get a Quote |
| FERMT1 Knockout HEK293 Cell Line | EDJ-KQ13472 | Human | 55612 | Details Get a Quote |
| FERMT3 Knockout HCT 116 Cell Line | EDJ-KQ23066 | Human | 83706 | Details Get a Quote |
| FER Knockout HCT 116 Cell Line | EDJ-KQ26004 | Human | 2241 | Details Get a Quote |
| FERMT2 Knockout HCT 116 Cell Line | EDJ-KQ32208 | Human | 10979 | Details Get a Quote |
| FERMT2 Knockout HeLa Cell Line | EDJ-KQ32209 | Human | 10979 | Details Get a Quote |
| FERMT1 Knockout A-549 Cell Line | EDJ-KQ43062 | Human | 55612 | Details Get a Quote |
| FERMT1 Knockout HCT 116 Cell Line | EDJ-KQ43063 | Human | 55612 | Details Get a Quote |
| FERMT1 Knockout HeLa Cell Line | EDJ-KQ43064 | Human | 55612 | Details Get a Quote |
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