FCGR2C
Fc Gamma Receptor IIc (CD32c) – Immune Regulation and Disease Association
Gene Information Card
| Symbol | FCGR2C |
|---|---|
| Full Name | Fc Fragment of IgG Receptor IIc (CD32c) |
| Gene Type | Protein coding |
| Chromosomal Location | 1q23.3 |
| NCBI Gene ID | 9103 ncbi.nlm.nih.gov/gene/9103 |
| Ensembl ID | ENSG00000203747 |
| UniProt ID | P31995 |
| OMIM ID | 604590 |
| HGNC ID | 3616 |
| Aliases | CD32c, FCGR2C, FcgammaRIIc, IGFR2C |
Description
FCGR2C encodes a member of the Fc gamma receptor family (FcγRIIc, CD32c) that binds the Fc region of immunoglobulin G (IgG). This receptor is expressed on natural killer (NK) cells and some myeloid cells, mediating antibody-dependent cellular cytotoxicity (ADCC) and immune complex clearance. The gene is located in the FCGR gene cluster on chromosome 1q23.3 and exhibits copy number variation and polymorphisms associated with autoimmune diseases and infection susceptibility.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus (SLE) | FCGR2C copy number variation alters IgG immune complex clearance, promoting autoantibody deposition and inflammation. | OMIM 604590; PMID 24905358 |
| Rheumatoid arthritis | Polymorphisms in FCGR2C affect FcγRIIc expression on NK cells, modulating ADCC and joint inflammation. | OMIM 604590; PMID 23028350 |
| Kawasaki disease | FCGR2C variants influence IgG receptor function, contributing to coronary artery vasculitis. | OMIM 604590; PMID 21841781 |
| Idiopathic thrombocytopenic purpura (ITP) | Altered FcγRIIc expression on NK cells impairs platelet clearance regulation. | OMIM 604590; PMID 19786223 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 2.3 | Low |
| Lung | 1.8 | Low |
| Whole blood | 4.1 | Medium |
| Bone marrow | 3.5 | Medium |
| Lymph node | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NK-92 (NK cell line) | 12.5 | High expression |
| THP-1 (monocyte) | 6.2 | Moderate expression |
| K-562 (erythroleukemia) | 0.8 | Low expression |
| Raji (Burkitt lymphoma) | 1.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs114945036 (stop-gain) | Nonsense | <0.01% (gnomAD) | Loss of function; truncated protein |
| rs201218628 (missense) | Missense | <0.01% (gnomAD) | Unknown functional effect |
| CNV (copy number variation) | Structural | Variable (population-dependent) | Altered gene dosage; associated with SLE and ITP |
Mutation functional classification
Loss of Function (LOF)
Nonsense variant rs114945036 introduces premature stop codon, leading to truncated non-functional FcγRIIc.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in FCGR2C.
Dominant Negative (DN)
No dominant-negative mutations described for FCGR2C.
View complete mutation data：
Gene Ontology (GO)
| • IgG binding (GO:0019864) | • Fc-gamma receptor activity (GO:0019770) |
| • cell surface (GO:0009986) | • signal transduction (GO:0007165) |
| • phagocytosis (GO:0006909) |
Pathways
• Fc gamma R-mediated phagocytosis (KEGG hsa04666)
• Natural killer cell mediated cytotoxicity (KEGG hsa04650)
• Immune System (Reactome R-HSA-168256)
Protein Summary
Fc gamma receptor IIc (CD32c) is a transmembrane glycoprotein of approximately 40 kDa that binds IgG immune complexes. It contains two extracellular Ig-like domains and a cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). Expressed primarily on NK cells, it triggers ADCC and cytokine release upon IgG engagement. Alternative splicing and copy number variation contribute to functional diversity and disease susceptibility.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FCGR2C Knockout HEK293 Cell Line | EDJ-KQ6460 | Human | 9103 | Details Get a Quote |
| FCGR2C Knockout A-549 Cell Line | EDJ-KQ30542 | Human | 9103 | Details Get a Quote |
| FCGR2C Knockout HCT 116 Cell Line | EDJ-KQ30543 | Human | 9103 | Details Get a Quote |
| FCGR2C Knockout HeLa Cell Line | EDJ-KQ30544 | Human | 9103 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
