FCER1G
High-affinity IgE receptor gamma subunit; key mediator of allergic and immune responses
Gene Information Card
| Symbol | FCER1G |
|---|---|
| Full Name | Fc fragment of IgE receptor Ig gamma |
| Gene Type | protein-coding |
| Chromosomal Location | 1q23.3 |
| NCBI Gene ID | 2207 ncbi.nlm.nih.gov/gene/2207 |
| Ensembl ID | ENSG00000185112 |
| UniProt ID | P30273 |
| OMIM ID | 147139 |
| HGNC ID | 3611 |
| Aliases | Fc epsilon receptor Ig gamma, FcERI gamma, FCRG, IGER |
Description
FCER1G encodes the gamma subunit of the high-affinity IgE receptor (FcεRI), a tetrameric complex (αβγ2) expressed on mast cells and basophils. The gamma subunit contains an immunoreceptor tyrosine-based activation motif (ITAM) that initiates downstream signaling upon IgE cross-linking, leading to degranulation, cytokine release, and allergic inflammation. FCER1G also associates with other Fc receptors (FcγRI, FcγRIIIa) and the T-cell receptor complex, broadening its role in immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Allergic rhinitis | Enhanced FcεRI signaling via FCER1G ITAM phosphorylation increases mast cell degranulation | PMID: 20674598 |
| Asthma | FCER1G polymorphisms linked to elevated IgE and airway hyperresponsiveness | PMID: 21546368 |
| Atopic dermatitis | Upregulation of FCER1G in skin mast cells contributes to chronic inflammation | PMID: 23583443 |
| Anaphylaxis | Cross-linking of FcεRI-bound IgE triggers systemic mast cell activation | PMID: 17413041 |
| Systemic lupus erythematosus | FCER1G variants associated with altered FcγR signaling and autoantibody production | PMID: 23273568 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole blood | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 6.1 | Low |
| Skin | 4.7 | Low |
| Bone marrow | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Mast cells (HMC-1) | 15.2 | High expression |
| Basophils (KU812) | 11.8 | High expression |
| Monocytes (THP-1) | 7.4 | Medium expression |
| NK cells (NK-92) | 5.1 | Low expression |
| T cells (Jurkat) | 2.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; predicted loss of function |
| c.82C>T (p.Arg28Trp) | Missense | 0.02% | Alters ITAM domain; reduced signaling |
| c.205_207del (p.Lys69del) | In-frame deletion | <0.01% | Disrupts transmembrane domain; impaired receptor assembly |
Mutation functional classification
Loss of Function (LOF)
Mutations in the start codon or ITAM domain (e.g., p.Met1?, p.Arg28Trp) impair receptor signaling and mast cell activation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in FCER1G.
Dominant Negative (DN)
Deletion in transmembrane domain (p.Lys69del) may exert dominant-negative effects by disrupting receptor complex formation.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Fc epsilon RI signaling pathway (KEGG: hsa04664)
• Fc gamma R-mediated phagocytosis (KEGG: hsa04666)
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Reactome: R-HSA-198933)
Protein Summary
FCER1G encodes the gamma subunit (FcRγ) of the high-affinity IgE receptor. This 86-amino-acid protein contains a single ITAM motif essential for signal transduction. FcRγ dimerizes with the FcεRI alpha and beta subunits to form the functional receptor on mast cells and basophils. Upon IgE cross-linking, ITAM tyrosines are phosphorylated by Src family kinases, recruiting Syk kinase and initiating downstream pathways (MAPK, PI3K, calcium flux) that lead to degranulation and cytokine production. FcRγ also pairs with FcγRI, FcγRIIIa, and the T-cell receptor CD3 complex, highlighting its pleiotropic role in immune signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FCER1G Knockout HEK293 Cell Line | EDJ-KQ1704 | Human | 2207 | Details Get a Quote |
| Fcer1g Knockout RAW 264.7 Cell Line | EDJ-KZ25 | Mouse | 14127 | Details Get a Quote |
| FCER1G Knockout HeLa Cell Line | EDJ-KQ53205 | Human | 2207 | Details Get a Quote |
| FCER1G Knockout A-549 Cell Line | EDJ-KQ61686 | Human | 2207 | Details Get a Quote |
| FCER1G Knockout HCT 116 Cell Line | EDJ-KQ70172 | Human | 2207 | Details Get a Quote |
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