FBXO36: F-Box Protein 36
A component of the SCF ubiquitin ligase complex with limited functional characterization
Gene Information Card
| Symbol | FBXO36 |
|---|---|
| Full Name | F-box protein 36 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 130888 ncbi.nlm.nih.gov/gene/130888 |
| Ensembl ID | ENSG00000162946 |
| UniProt ID | Q8NEA4 |
| OMIM ID | 609104 |
| HGNC ID | 28910 |
| Aliases | F-box only protein 36, MGC131831 |
Description
FBXO36 encodes a member of the F-box protein family, which are components of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex. F-box proteins function as substrate recognition subunits, targeting specific proteins for ubiquitination and subsequent proteasomal degradation. FBXO36 contains an F-box domain and is involved in protein turnover regulation, though its specific substrates and biological roles remain incompletely understood.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 2.1 | Low |
| Lung | 1.8 | Low |
| Liver | 1.5 | Low |
| Kidney | 1.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.0 | Moderate expression in kidney-derived cell line |
| HeLa | 2.5 | Low expression in cervical cancer cells |
| K562 | 1.0 | Low expression in leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
| c.250G>A (p.Gly84Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported
Gain of Function (GOF)
No confirmed gain-of-function mutations reported
Dominant Negative (DN)
No confirmed dominant-negative mutations reported
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • ubiquitin-protein transferase activity (GO:0004842) |
| • protein ubiquitination (GO:0016567) | • ubiquitin ligase complex (GO:0000151) |
Pathways
• Ubiquitin-mediated proteolysis (KEGG: hsa04120)
• SCF complex assembly (Reactome: R-HSA-8951664)
Protein Summary
FBXO36 is a 421-amino acid protein containing an N-terminal F-box domain (residues 30-75) that mediates interaction with SKP1, and a C-terminal domain of unknown function. It is predicted to localize to the cytoplasm and nucleus. No three-dimensional structure has been determined experimentally.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FBXO36 Knockout HEK293 Cell Line | EDJ-KQ9255 | Human | 130888 | Details Get a Quote |
| FBXO36 Knockout A-549 Cell Line | EDJ-KQ34608 | Human | 130888 | Details Get a Quote |
| FBXO36 Knockout HCT 116 Cell Line | EDJ-KQ35855 | Human | 130888 | Details Get a Quote |
| FBXO36 Knockout HeLa Cell Line | EDJ-KQ35856 | Human | 130888 | Details Get a Quote |
