FASTK
Fas-Activated Serine/Threonine Kinase
Gene Information Card
| Symbol | FASTK |
|---|---|
| Full Name | Fas-Activated Serine/Threonine Kinase |
| Gene Type | Protein coding |
| Chromosomal Location | 7q36.1 |
| NCBI Gene ID | 10922 ncbi.nlm.nih.gov/gene/10922 |
| Ensembl ID | ENSG00000164821 |
| UniProt ID | Q9NYY8 |
| OMIM ID | 606965 |
| HGNC ID | 3595 |
| Aliases | FAST, STK10 |
Description
FASTK encodes a serine/threonine kinase that is activated by Fas-induced apoptosis. The protein localizes to mitochondria and is involved in mitochondrial RNA processing and splicing, particularly of the ND5 subunit of complex I. It plays a role in regulating apoptosis and mitochondrial function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Mitochondrial Complex I Deficiency | Impaired ND5 RNA processing due to FASTK dysfunction | PMID: 25838379 |
| Cancer (various) | Altered FASTK expression affects apoptosis and mitochondrial metabolism | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Heart | 8.3 | Medium |
| Skeletal Muscle | 7.1 | Medium |
| Liver | 4.2 | Low |
| Brain | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | High expression |
| HeLa | 8.5 | Medium expression |
| K562 | 6.1 | Medium expression |
| HepG2 | 4.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown effect |
| c.245C>T | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations likely lead to truncated protein and loss of kinase activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity (GO:0004674) | • ATP binding (GO:0005524) |
| • mRNA processing (GO:0006397) | • apoptotic process (GO:0006915) |
| • mitochondrion (GO:0005739) |
Pathways
• Fas Signaling Pathway
• Apoptosis
• Mitochondrial RNA Processing
Protein Summary
FASTK is a 549-amino acid serine/threonine kinase with a mitochondrial targeting sequence. It phosphorylates substrates involved in apoptosis and is essential for proper splicing of mitochondrial ND5 mRNA. The protein contains a kinase domain and a FAST_1 domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FASTK Knockout HEK293 Cell Line | EDJ-KQ3678 | Human | 10922 | Details Get a Quote |
| FASTKD2 Knockout HEK293 Cell Line | EDJ-KQ7023 | Human | 22868 | Details Get a Quote |
| FASTKD1 Knockout HEK293 Cell Line | EDJ-KQ13450 | Human | 79675 | Details Get a Quote |
| FASTKD5 Knockout HEK293 Cell Line | EDJ-KQ13451 | Human | 60493 | Details Get a Quote |
| FASTKD2 Knockout A-549 Cell Line | EDJ-KQ33093 | Human | 22868 | Details Get a Quote |
| FASTKD2 Knockout HCT 116 Cell Line | EDJ-KQ33094 | Human | 22868 | Details Get a Quote |
| FASTKD2 Knockout HeLa Cell Line | EDJ-KQ33095 | Human | 22868 | Details Get a Quote |
| FASTKD1 Knockout A-549 Cell Line | EDJ-KQ43008 | Human | 79675 | Details Get a Quote |
| FASTKD1 Knockout HeLa Cell Line | EDJ-KQ43010 | Human | 79675 | Details Get a Quote |
| FASTKD5 Knockout A-549 Cell Line | EDJ-KQ43011 | Human | 60493 | Details Get a Quote |
| FASTKD5 Knockout HCT 116 Cell Line | EDJ-KQ43012 | Human | 60493 | Details Get a Quote |
| FASTKD5 Knockout HeLa Cell Line | EDJ-KQ43013 | Human | 60493 | Details Get a Quote |
| FASTK Knockout A-549 Cell Line | EDJ-KQ25663 | Human | 10922 | Details Get a Quote |
| FASTK Knockout HCT 116 Cell Line | EDJ-KQ25664 | Human | 10922 | Details Get a Quote |
| FASTK Knockout HeLa Cell Line | EDJ-KQ25665 | Human | 10922 | Details Get a Quote |
