FANCD2OS
FANCD2 Opposite Strand
Gene Information Card
| Symbol | FANCD2OS |
|---|---|
| Full Name | FANCD2 opposite strand |
| Gene Type | protein-coding |
| Chromosomal Location | 3p25.3 |
| NCBI Gene ID | 100128731 ncbi.nlm.nih.gov/gene/100128731 |
| Ensembl ID | ENSG00000214548 |
| UniProt ID | Q6ZP29 |
| OMIM ID | 613984 |
| HGNC ID | 37271 |
| Aliases | MGC26733, dJ1033B10.2 |
Description
FANCD2OS (FANCD2 opposite strand) is a protein-coding gene located on chromosome 3p25.3. It is transcribed from the opposite strand of the FANCD2 gene. The function of the encoded protein is not fully characterized, but it may play a role in cellular processes related to DNA repair or cell cycle regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not applicable | No evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Brain | 1.5 | Low |
| Lung | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.8 | Low expression |
| HeLa | 1.5 | Low expression |
| K562 | 1.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The FANCD2OS protein (UniProt Q6ZP29) is a 244-amino acid protein with unknown function. No structural domains or functional motifs have been characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FANCD2OS Knockout HEK293 Cell Line | EDJ-KQ7533 | Human | 115795 | Details Get a Quote |
| FANCD2OS Knockout HeLa Cell Line | EDJ-KQ57963 | Human | 115795 | Details Get a Quote |
| FANCD2OS Knockout A-549 Cell Line | EDJ-KQ66453 | Human | 115795 | Details Get a Quote |
| FANCD2OS Knockout HCT 116 Cell Line | EDJ-KQ74875 | Human | 115795 | Details Get a Quote |
