FAM168A: A Gene Encoding a Protein of Unknown Function
Comprehensive genomic and proteomic overview of FAM168A (family with sequence similarity 168 member A).
Gene Information Card
| Symbol | FAM168A |
|---|---|
| Full Name | family with sequence similarity 168 member A |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.4 |
| NCBI Gene ID | 23201 ncbi.nlm.nih.gov/gene/23201 |
| Ensembl ID | ENSG00000137710 |
| UniProt ID | Q92537 |
| OMIM ID | 616448 |
| HGNC ID | 28758 |
| Aliases | MGC12966, bA155J5.1 |
Description
FAM168A is a protein-coding gene located on chromosome 11q13.4. The encoded protein has no well-characterized function, but it is conserved in vertebrates. Expression data suggest broad tissue distribution. No definitive disease associations have been established in major databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 6.2 | Low |
| Heart | 4.8 | Low |
| Liver | 3.1 | Low |
| Kidney | 5.0 | Low |
| Lung | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 5.5 | Low expression |
| HeLa | 4.2 | Low expression |
| K562 | 3.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
Pathways
• No curated pathways
Protein Summary
The FAM168A protein (UniProt Q92537) is 272 amino acids long with a molecular mass of approximately 30 kDa. It contains no known functional domains and its biological role remains uncharacterized. Subcellular localization is predicted to be cytoplasmic.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAM168A Knockout HEK293 Cell Line | EDJ-KQ13407 | Human | 23201 | Details Get a Quote |
| FAM168A Knockout A-549 Cell Line | EDJ-KQ42926 | Human | 23201 | Details Get a Quote |
| FAM168A Knockout HCT 116 Cell Line | EDJ-KQ42927 | Human | 23201 | Details Get a Quote |
| FAM168A Knockout HeLa Cell Line | EDJ-KQ42928 | Human | 23201 | Details Get a Quote |
| FAM168A Knockout NCI-H1299 Cell Line | EDJ-KZ234 | Human | 23201 | Details Get a Quote |
| FAM168A Knockout T98G Cell Line | EDJ-KZ235 | Human | 23201 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
