FAM120AOS
Family With Sequence Similarity 120A Opposite Strand
Gene Information Card
| Symbol | FAM120AOS |
|---|---|
| Full Name | Family With Sequence Similarity 120A Opposite Strand |
| Gene Type | Protein coding |
| Chromosomal Location | 9q22.31 |
| NCBI Gene ID | 100037417 ncbi.nlm.nih.gov/gene/100037417 |
| Ensembl ID | ENSG00000203782 |
| UniProt ID | A6NKD9 |
| OMIM ID | 614790 |
| HGNC ID | 33787 |
| Aliases | C9orf131, bA203J24.7, FLJ46321 |
Description
FAM120AOS (Family With Sequence Similarity 120A Opposite Strand) is a protein-coding gene located on chromosome 9q22.31. It is transcribed from the opposite strand of the FAM120A gene. The encoded protein contains a coiled-coil domain and is involved in RNA binding and protein-protein interactions. Expression is observed in multiple tissues, with highest levels in testis and brain. Limited functional studies suggest a role in cellular signaling and RNA metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Lung | 5.1 | Low |
| Liver | 3.2 | Low |
| Kidney | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.0 | Moderate expression |
| HeLa | 4.5 | Low expression |
| K562 | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • protein binding |
| • cytoplasm |
Pathways
• No curated pathways
Protein Summary
The FAM120AOS protein (UniProt A6NKD9) is 441 amino acids long and contains a coiled-coil domain. It is predicted to localize to the cytoplasm and may function in RNA binding and protein-protein interactions. No enzymatic activity or disease-associated mutations have been characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAM120AOS Knockout HEK293 Cell Line | EDJ-KQ52088 | Human | 158293 | Details Get a Quote |
| FAM120AOS Knockout HeLa Cell Line | EDJ-KQ58781 | Human | 158293 | Details Get a Quote |
| FAM120AOS Knockout A-549 Cell Line | EDJ-KQ67263 | Human | 158293 | Details Get a Quote |
| FAM120AOS Knockout HCT 116 Cell Line | EDJ-KQ75662 | Human | 158293 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
